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In vitro effect of paediatric liquid medicines on deciduous enamel exposed to biofilm.
MedLine Citation:
PMID:  23351218     Owner:  NLM     Status:  Publisher    
Abstract Objective. This study aimed to assess the in vitro effects of paediatric liquid medicines on deciduous enamel exposed to biofilms. Methods. Fragments (n = 25) of first primary molars were covered by nail varnish, leaving a 22 mm(2) exposure area. Specimens were fixed in polystyrene plates containing BHI broth media. Pooled human saliva was added to form a mature biofilm on fragments over a 10-day period in microaerophilic conditions. Specimens were divided into groups (n = 5 per group) and treated (50 μL) daily for 1 min over 1 week as follows: G1 = 10% sucrose solution (positive control); G2 = Dimetapp Elixir® (antihistamine); G3 = Claritin® (antihistamine); and G4 = Klaricid® (antibiotic). Five other fragments, without treatment and inoculum represented the blank controls. The covered area for each specimen represented the negative control. Cross-sectional hardness of the enamel was used as a demineralization indicator. Results. All treatment groups showed hardness loss compared to the corresponding negative controls (p < 0.05). Among the treatment groups, G2 exhibited the greatest demineralization pattern (p < 0.05) followed by G3, G1 and G4. Conclusion. All medicines caused deciduous enamel demineralization in the presence of biofilm. The greatest hardness loss was observed after treatment with Dimetapp Elixir®.
Daniela Novaes Soares; Andréa Gonçalves Antonio; Viviane Santos da Silva Pierro; Natalia Lopes Pontes Iorio; Kátia Regina Netto Dos Santos; Lucianne Cople Maia
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Acta odontologica Scandinavica     Volume:  -     ISSN:  1502-3850     ISO Abbreviation:  Acta Odontol. Scand.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370344     Medline TA:  Acta Odontol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Paediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.
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