Document Detail

In vitro effect of ascorbic acid on the proliferation of bovine scleral and Tenon's capsule fibroblasts.
MedLine Citation:
PMID:  9590594     Owner:  NLM     Status:  MEDLINE    
The success of glaucoma filtration surgery depends mainly on an incomplete wound healing process in the area of the fistula. Since Kornblueth and Tenenbaum's investigations in 1956 it has been known that aqueous humour has intrinsic antiproliferative properties. It is assumed that ascorbic acid is involved in the regulation of the wound healing process after filtration surgery. To evaluate the antiproliferative effect of ascorbic acid in vitro, we used cultured fibroblasts of bovine Tenon's capsule and bovine sclera. Incubation of these cells with ascorbic acid at concentrations ranging from 0.5 to 3 mM/L led to dose-dependent inhibition of cell proliferation. The half-maximal inhibitory concentration was 1.0 mM/L for both cell types. Physiological concentrations of ascorbic acid may be valuable in the pharmacological prevention of failure of glaucoma filtration surgery. However, extensive clinical investigations are needed to clarify whether topical intraoperative or postoperative as well as oral administration of ascorbic acid inhibits fibroblast proliferation after glaucoma filtration surgery.
P O Denk; M Knorr
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  8     ISSN:  1120-6721     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    1998 Jan-Mar
Date Detail:
Created Date:  1998-07-06     Completed Date:  1998-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  37-41     Citation Subset:  IM    
Department of Ophthalmology, University of Tübingen, Germany.
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MeSH Terms
Ascorbic Acid / pharmacology*
Cell Count
Cell Division / drug effects
Cells, Cultured / drug effects
Connective Tissue*
Dose-Response Relationship, Drug
Fibroblasts / cytology,  drug effects*
Sclera / cytology*,  drug effects
Wound Healing / drug effects
Reg. No./Substance:
50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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