Document Detail


[In vitro effect of the S3Pvac vaccine against cysticercosis in human mononucleate cells].
MedLine Citation:
PMID:  23629747     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
INTRODUCTION. Neurocysticercosis (NCC) is a parasitic infection caused by the establishment of Taenia solium cysticerci in the central nervous system. The larval stage of the parasite also affects the pig, which is the essential intermediate host for transmission. For this reason, many researchers have focused on identifying protective antigens to prevent swine cysticercosis and interrupt the transmission. These include S3Pvac vaccine antigens. Vaccine is constituted by three protective synthetic peptides: KETc1, KETc12 and GK1. AIM. To evaluate the effect of the vaccine peptides KETc1, KETc12 and GK1 in mononuclear cells of patients with neuro-cysticercosis and healthy individuals. SUBJECTS AND METHODS. Comparative, prospective, transverse study. We studied the proliferation and cytokine profile induced by the three peptides in mononuclear cells from three patients with active NCC, 16 patients by calcified NCC and 16 healthy subjects. RESULTS. KETc1 induces low levels of proliferation in cells from patients with active and controlled NCC, both in lymphocytes and in monocytes. KETc12 and GK-1 induce positive proliferation levels of monocytes in healthy subjects. CONCLUSIONS. KETc1 peptide could be used as an adjuvant in the treatment of patients with active NCC, as induced a Th2 response also GK1 peptide as stimulator of monocyte/macrophage in immunizations with other proteins.
Abstract available from the publisher.
Authors:
M A Diaz-Orea; J M Mijares; R Arcega; E Gomez-Conde; V O Castellanos-Sanchez; R Briones-Rojas; J C Flores-Alonso; M A Marin-Briones; G Santos-Lopez
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Revista de neurologia     Volume:  56     ISSN:  1576-6578     ISO Abbreviation:  Rev Neurol     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706841     Medline TA:  Rev Neurol     Country:  Spain    
Other Details:
Languages:  spa     Pagination:  456-63     Citation Subset:  IM    
Affiliation:
Benemerita Universidad Autonoma de Puebla, Puebla, Mexico.
Vernacular Title:
Efecto in vitro de la vacuna S3Pvac contra cisticercosis en celulas mononucleares humanas.
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