Document Detail

In vitro distribution of porphyrin metabolites from 10(-3) M delta-aminolevulinic acid in primary neural tissue cultures.
MedLine Citation:
PMID:  3587504     Owner:  NLM     Status:  MEDLINE    
The distribution of porphyrin metabolites (uro-7-6-5-copro-3-proto-heme) from 10(-3) M delta-aminolevulinic acid (ALA) in neuronal and glial primary cultures was examined by an isotopic technique. In both cell types, 8-9% of the total production (cell + medium) was found in the cells and more than 90% in the medium. In both the cells and the medium the predominant porphyrin fraction was uro + 7 carboxylic. The heme fraction of the cells was also very high. Through the exclusion of ALA-synthetase activity, the "Uroporphyria-like-model" of "hepatic porphyria" was demonstrated.
I Durkó; A Juhász
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurochemical research     Volume:  12     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-07-07     Completed Date:  1987-07-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  465-8     Citation Subset:  IM    
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MeSH Terms
Aminolevulinic Acid / metabolism*
Brain / metabolism*
Brain Chemistry
Chick Embryo
Chromatography, Thin Layer
Levulinic Acids / metabolism*
Neuroglia / analysis,  metabolism*
Neurons / analysis,  metabolism
Porphyrins / analysis,  biosynthesis*
Reg. No./Substance:
0/Levulinic Acids; 0/Porphyrins; 106-60-5/Aminolevulinic Acid

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