| In vitro diffusion of lidocaine across endotracheal tube cuffs. | |
| | |
MedLine Citation:
|
PMID: 10078409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Lidocaine diffuses across endotracheal tube cuffs, which may serve as a reservoir for local anesthetic to assist in the prevention of ETT-induced cough while emerging from general anesthesia. However, the rate of diffusion is slow. Two techniques, alkalization and warming, may increase the proportion of uncharged drug available for diffusion. The purpose of this study is to determine the effectiveness of warming alkalization or warming with alkalization on diffusion. METHODS: Four preparations of lidocaine 4% were studied. Group (Gr) L-lidocaine (24 degrees C), Gr WL--warmed lidocaine (38 degrees C), Gr AL--alkalized lidocaine (24 degrees C), Gr WAL--warmed, alkalized lidocaine (38 degrees C). Twenty-four Mallinckrodt 8.0 ID (Mallinckrodt Critical Care Division of Mallinckrodt, Inc., Glens Falls, New York) endotracheal tube cuffs were filled with 6 ml of one of the four preparations. They were then placed in a 20 ml water bath at 38 degrees C and samples were drawn from the water bath at intervals for up to 360 min. The lidocaine concentration in each sample was determined by gas chromatography. RESULTS: The highest lidocaine concentration was reached in Gr WAL (410.98 +/- 8.53 micrograms.ml-1) after 300 min and then decreased to 376.18 +/- 4.59 micrograms.ml-1 after 360 min. In Gr AL the highest concentration (235.05 +/- 2.99 micrograms.ml-1) was reached after 360 min. Lidocaine concentrations in Gr L and WL after 360 min were 3.19 +/- 1.16 micrograms.ml-1 and 4.32 +/- 2.02 micrograms.ml-1 respectively. CONCLUSION: Alkalization with or without warming, but not warming alone, promotes lidocaine diffusion from endotracheal tube cuff. |
| | |
Authors:
|
C J Huang; M C Tsai; C T Chen; C R Cheng; K H Wu; T T Wei |
Related Documents
:
|
17347269 - Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilat... 121159 - Some structure-activity relationships of iodophorous iodine complex compounds. part ii.... 7890759 - Polylysine and cvim sequences of k-rasb dictate specificity of prenylation and confer r... 3364569 - Thromboxane synthesis inhibitors and postprandial jejunal capillary exchange capacity. 12141269 - Assuring quality and performance of sustained and controlled release parenterals: works... 16995799 - Controlled in vivo degradation of genipin crosslinked polyethylene glycol hydrogels wit... 15501519 - The cdna for leucomyosuppressin in blattella germanica and molecular evolution of insec... 22614709 - Gold-nanosphere formation using food sample endogenous polyphenols for in-vitro assessm... 11990039 - Polymerase chain reaction-based methods for detection of listeria monocytogenes: toward... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Canadian journal of anaesthesia = Journal canadien d'anesthésie Volume: 46 ISSN: 0832-610X ISO Abbreviation: Can J Anaesth Publication Date: 1999 Jan |
Date Detail:
|
Created Date: 1999-05-11 Completed Date: 1999-05-11 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8701709 Medline TA: Can J Anaesth Country: CANADA |
Other Details:
|
Languages: eng Pagination: 82-6 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan. sean@ms2.mmh.org.tw |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkalies
/
chemistry Analysis of Variance Anesthesia Recovery Period Anesthetics, Local / chemistry* Chromatography, Gas Cough / prevention & control Diffusion Equipment Design Hot Temperature Humans Hydrogen-Ion Concentration Immersion Intubation, Intratracheal / adverse effects, instrumentation* Lidocaine / chemistry* Materials Testing Sodium Bicarbonate / chemistry Time Factors Water |
| Chemical | |
Reg. No./Substance:
|
0/Alkalies; 0/Anesthetics, Local; 137-58-6/Lidocaine; 144-55-8/Sodium Bicarbonate; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anesthetic modulation of myocardial ischemia and reperfusion injury in pigs: comparison between halo...
Next Document: Wire-guided endobronchial blockade in a patient with a limited mouth opening.