| THE IN VITRO DESENSITIZATION OF SENSITIVE CELLS BY TRYPSIN. | |
| | |
| Jump to Full Text | |
MedLine Citation:
|
PMID: 14238934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Peritoneal exudate cells from animals exhibiting delayed hypersensitivity are inhibited from migrating in vitro by specific antigen. This inhibition is completely abolished by pretreatment of the sensitive cells with trypsin. The action of trypsin is prevented by soybean trypsin inhibitor. The results of experiments with mixtures of normal and sensitive cells suggest that trypsin alters an immunologic capacity of the sensitive cells. Trypsinized sensitive cells are capable of passively transferring delayed hypersensitivity and peritoneal cells taken from recipient animals are inhibited from migrating in vitro by specific antigen. These results suggest that the cells rapidly resynthesize the material removed by trypsin. The possible nature of the material removed by trypsin is discussed. |
| | |
Authors:
|
J R DAVID; H S LAWRENCE; L THOMAS |
Related Documents
:
|
543374 - Inhibition of proliferation of ehrlich ascites carcinoma cells in vitro and in vivo by ... 2074264 - Ehrlich ascites tumour cells show tissue-specific adherence and modify their shape upon... 10661864 - Fast control of dna replication in response to hypoxia and to inhibited protein synthes... 3609324 - Acidification of the interior of ehrlich ascites tumor cells by nigericin inhibits dna ... 7543484 - New knowledge in primary biliary cirrhosis. 16690214 - Maturation of firing pattern in chick vestibular nucleus neurons. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of experimental medicine Volume: 120 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1964 Dec |
Date Detail:
|
Created Date: 1965-04-01 Completed Date: 1996-12-01 Revised Date: 2011-09-28 |
Medline Journal Info:
|
Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1189-200 Citation Subset: OM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Desensitization, Immunologic* Exudates and Transudates* Guinea Pigs* Immunization* Pharmacology* Research* Tissue Culture Techniques* Trypsin* |
| Chemical | |
Reg. No./Substance:
|
EC 3.4.21.4/Trypsin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
|
Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1964 by The Rockefeller Institute Received Day: 24 Month: 7 Year: 1964 Print publication date: Day: 30 Month: 11 Year: 1964 Volume: 120 Issue: 6 First Page: 1189 Last Page: 1200 ID: 2137791 PubMed Id: 14238934 |
| THE IN VITRO DESENSITIZATION OF SENSITIVE CELLS BY TRYPSIN | |
| John R. David | |
| H. S. Lawrence | |
| L. Thomas | |
| From the Department of Medicine, New York University School of Medicine, New York |
|
Article Categories:
|
|
Previous Document: ON THE RELATIONSHIPS BETWEEN THE GAMMA-GLOBULIN GENES OF THE GM SYSTEM. A STUDY OF GM GENE PRODUCTS ...
Next Document: THE IDENTIFICATION AND ISOLATION OF TWO MOUSE-TOXIC PROTEIN COMPONENTS IN EXTRACTS FROM PASTEURELLA ...