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THE IN VITRO DESENSITIZATION OF SENSITIVE CELLS BY TRYPSIN.
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MedLine Citation:
PMID:  14238934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peritoneal exudate cells from animals exhibiting delayed hypersensitivity are inhibited from migrating in vitro by specific antigen. This inhibition is completely abolished by pretreatment of the sensitive cells with trypsin. The action of trypsin is prevented by soybean trypsin inhibitor. The results of experiments with mixtures of normal and sensitive cells suggest that trypsin alters an immunologic capacity of the sensitive cells. Trypsinized sensitive cells are capable of passively transferring delayed hypersensitivity and peritoneal cells taken from recipient animals are inhibited from migrating in vitro by specific antigen. These results suggest that the cells rapidly resynthesize the material removed by trypsin. The possible nature of the material removed by trypsin is discussed.
Authors:
J R DAVID; H S LAWRENCE; L THOMAS
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  120     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1964 Dec 
Date Detail:
Created Date:  1965-04-01     Completed Date:  1996-12-01     Revised Date:  2011-09-28    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1189-200     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Desensitization, Immunologic*
Exudates and Transudates*
Guinea Pigs*
Immunization*
Pharmacology*
Research*
Tissue Culture Techniques*
Trypsin*
Chemical
Reg. No./Substance:
EC 3.4.21.4/Trypsin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1964 by The Rockefeller Institute
Received Day: 24 Month: 7 Year: 1964
Print publication date: Day: 30 Month: 11 Year: 1964
Volume: 120 Issue: 6
First Page: 1189 Last Page: 1200
ID: 2137791
PubMed Id: 14238934

THE IN VITRO DESENSITIZATION OF SENSITIVE CELLS BY TRYPSIN
John R. David
H. S. Lawrence
L. Thomas
From the Department of Medicine, New York University School of Medicine, New York


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