| In vitro depletion of clonogenic cells in adult acute lymphoblastic leukemia with a CD10 (anti-cALLA) monoclonal antibody. | |
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MedLine Citation:
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PMID: 3308484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A semi-solid medium colony assay was used in common acute lymphoblastic leukemia (cALL) to test growth inhibition of leukemic progenitors (CFU-L) after exposure to monoclonal antibodies (MoAbs) directed against CD10 and CD9 antigens. Peripheral or bone marrow cells from 15 patients were plated after exposure to various concentrations of ALB2, a CD10 cytotoxic MoAb, followed by complement lysis. CFU-L inhibition was complete (no residual colony) in 5 cases (33%), marked (greater than or equal to 95%) in 4 cases (27%), but only moderate (64% +/- 28) in 6 cases (40%). This inhibition was not related to the percentage of cALLA positive cells before exposure to MoAb. In addition, cells of 5 patients were exposed to BA1 (CD24) + complement. In these cases, the proportion of CFU-L inhibition was equal to or higher than with ALB2. In 3 cases, cells were exposed to an association of ALB2 and SB4 (CD19) MoAbs followed by complement lysis, with a marked inhibition (greater than or equal to 99%) in 2/3 cases. These observations give supplementary support to the use of several MoAbs directed against various antigens present at early stages of B differentiation. |
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Authors:
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J P Marie; C Choquet; J Y Perrot; D Thevenin; C Pillier; C Boucheix; R Zittoun |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of cancer & clinical oncology Volume: 23 ISSN: 0277-5379 ISO Abbreviation: Eur J Cancer Clin Oncol Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-11-20 Completed Date: 1987-11-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112045 Medline TA: Eur J Cancer Clin Oncol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1181-7 Citation Subset: IM |
Affiliation:
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Service d'Hématologie de l'Hôtel-Dieu de Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antibodies, Monoclonal / therapeutic use Bone Marrow Transplantation Cell Separation Colony-Forming Units Assay Complement System Proteins / immunology Cytotoxicity, Immunologic Humans Leukemia, Lymphoid / therapy* Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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