| In vitro degradation and controlled release behavior of D,L-PLGA50 and PCL-b-D,L-PLGA50 copolymer microspheres. | |
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MedLine Citation:
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PMID: 16005093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blank and bovine serum albumin (BSA)-loaded microspheres based on poly(lactic-acid-alt-glycolic acid) (D,L-PLGA50) and poly(epsilon-caprolactone)-b-poly(lactic-acid-alt-glycolic acid) (PCL-b-D,L-PLGA50) were successfully fabricated using water-in-oil-in-water (w/o/w) double-emulsion extraction/evaporation technique. In vitro degradation of the blank microspheres was characterized by techniques including nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The PCL-b-D,L-PLGA50 copolymer (Mn: number-average molecular weight, Mw: weight-average molecular weight, Mn=44800, Mw/Mn=MWD=1.24, epsilon-caprolactone (CL) %=20.4% in molar ratio) had similar rate of molecular weight reduction compared with the D,L-PLGA50 copolymer before 5 weeks of in vitro degradation. The BSA % loading efficiency of microspheres was mainly controlled by both block copolymer composition and macromolecular architecture, while the sequence structure and the molecular weight of copolymer had no apparent effect on it. Significantly, The PCL-b-D,L-PLGA50 copolymer microspheres showed good release profiles with a nearly constant release during 20-110 days. |
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Authors:
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Chang-Ming Dong; Ying-Zhi Guo; Kun-Yuan Qiu; Zhong-Wei Gu; Xin-De Feng |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 107 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-12 Completed Date: 2005-11-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
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Languages: eng Pagination: 53-64 Citation Subset: IM |
Affiliation:
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Department of Polymer Science and Engineering, School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, PR China. cmdong@sjtu.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calorimetry, Differential Scanning Cattle Chromatography, Gel Delayed-Action Preparations / chemistry, metabolism* Lactic Acid / chemistry, metabolism* Magnetic Resonance Spectroscopy Microscopy, Electron, Scanning Microspheres* Molecular Weight Polyglycolic Acid / chemistry, metabolism* Polymers / chemistry, metabolism* Serum Albumin, Bovine / metabolism Temperature Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Polymers; 0/Serum Albumin, Bovine; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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