| In vitro cytotoxicity of glycol ethers and oxidation products in CHO cells. | |
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MedLine Citation:
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PMID: 4024159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cytotoxicity of several glycol ethers and of some of their oxidation products, the corresponding alkoxy acetates, was compared in Chinese hamster ovary (CHO-K1) cells without metabolic activation. Cytotoxicity was measured in terms of cloning formation ability, and EC50 values (concentrations allowing 50% of the seeded cells to form colonies) were estimated. The results, in the case of unmetabolized glycol ethers tested, showed an increase in toxicity with increasing chain length. The cytotoxicity of the corresponding alkoxy acetates, however, did not exhibit a trend in parallel with the chemical structure. 2-Methoxypropionic acid was somewhat less cytotoxic than the alkoxy acetic acids investigated. It is concluded that gross cytotoxicity to dividing cells is not the predominant mechanism for the teratogenicity or myelotoxicity and testes toxicity of methoxy- and ethoxyethanol, which produce these effects after oxidation to their corresponding alkoxy acetates. |
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Authors:
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R Jäckh; H P Gelbke; G Helmstädter |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Toxicology letters Volume: 26 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-09-13 Completed Date: 1985-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 73-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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metabolism,
toxicity Animals Cell Division / drug effects Cricetinae Cricetulus Ethylene Glycols / metabolism, toxicity* Female Ovary / drug effects*, metabolism Oxidation-Reduction Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Ethylene Glycols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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