Document Detail

In vitro cytotoxicity of glycol ethers and oxidation products in CHO cells.
MedLine Citation:
PMID:  4024159     Owner:  NLM     Status:  MEDLINE    
The cytotoxicity of several glycol ethers and of some of their oxidation products, the corresponding alkoxy acetates, was compared in Chinese hamster ovary (CHO-K1) cells without metabolic activation. Cytotoxicity was measured in terms of cloning formation ability, and EC50 values (concentrations allowing 50% of the seeded cells to form colonies) were estimated. The results, in the case of unmetabolized glycol ethers tested, showed an increase in toxicity with increasing chain length. The cytotoxicity of the corresponding alkoxy acetates, however, did not exhibit a trend in parallel with the chemical structure. 2-Methoxypropionic acid was somewhat less cytotoxic than the alkoxy acetic acids investigated. It is concluded that gross cytotoxicity to dividing cells is not the predominant mechanism for the teratogenicity or myelotoxicity and testes toxicity of methoxy- and ethoxyethanol, which produce these effects after oxidation to their corresponding alkoxy acetates.
R Jäckh; H P Gelbke; G Helmstädter
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  26     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-09-13     Completed Date:  1985-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  IM    
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MeSH Terms
Acetates / metabolism,  toxicity
Cell Division / drug effects
Ethylene Glycols / metabolism,  toxicity*
Ovary / drug effects*,  metabolism
Structure-Activity Relationship
Reg. No./Substance:
0/Acetates; 0/Ethylene Glycols

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