Document Detail

In vitro cytotoxicity and differential cellular sensitivity of new N-methyl and N-propargyl urea and nitrosourea derivatives of diamino acids against sixty human NCI tumor cell lines.
MedLine Citation:
PMID:  8476204     Owner:  NLM     Status:  MEDLINE    
The in vitro cytotoxicity and differential cellular sensitivity of a series of new N-methyl and N-propargyl urea and nitrosourea derivatives of diamino acids were determined in the National Cancer Institute's primary antitumor drug screen. These compounds have a level of cytotoxic activity comparable to BCNU, CCNU and Methyl-CCNU. In this series of diamino acid derivatives, the N-nitroso group does not seems to be essential to the in vitro activity of these compounds. The N-Propargyl derivatives have shown significantly more differential cellular sensitivity than the N-Methyl derivatives. Hence, the N-Propargyl group seems to induce more cell line specificity in our compounds. Based on their in vitro cytotoxic activity and mostly their pattern of differential cellular sensitivity, two compounds described in this work have been selected by the NCI for further development. These compounds are currently being screened in animal models.
G Gallant; R Salvador; H Dulude
Related Documents :
15498654 - Chlamydocin-hydroxamic acid analogues as histone deacetylase inhibitors.
8568814 - Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase ...
18434144 - Identification of long chain alkylidenemalonates as novel small molecule modulators of ...
19236044 - Synthesis and applications of polyamine amino acid residues: improving the bioactivity ...
23138254 - Dynamic molecular behavior of semi-fluorinated oleic, elaidic and stearic acids in the ...
10638754 - A highly unsaturated fatty acid predicts carbon transfer between primary producers and ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  13     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1993 Jan-Feb
Date Detail:
Created Date:  1993-05-18     Completed Date:  1993-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Medicinal Chemistry Laboratory, Faculty of Pharmacy, University of Montréal, Québec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents / pharmacology*
Drug Screening Assays, Antitumor
Neoplasms, Experimental / drug therapy*
Nitrosourea Compounds / pharmacology*
Tumor Cells, Cultured / drug effects
Urea / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Antineoplastic Agents; 0/Nitrosourea Compounds; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Complete regression of advanced liposarcoma of the anterior chest wall with interferon-alpha and tum...
Next Document:  Butyramide and monobutyrin: growth inhibitory and differentiating agents.