Document Detail


In vitro cytotoxicity and differential cellular sensitivity of new N-methyl and N-propargyl urea and nitrosourea derivatives of diamino acids against sixty human NCI tumor cell lines.
MedLine Citation:
PMID:  8476204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro cytotoxicity and differential cellular sensitivity of a series of new N-methyl and N-propargyl urea and nitrosourea derivatives of diamino acids were determined in the National Cancer Institute's primary antitumor drug screen. These compounds have a level of cytotoxic activity comparable to BCNU, CCNU and Methyl-CCNU. In this series of diamino acid derivatives, the N-nitroso group does not seems to be essential to the in vitro activity of these compounds. The N-Propargyl derivatives have shown significantly more differential cellular sensitivity than the N-Methyl derivatives. Hence, the N-Propargyl group seems to induce more cell line specificity in our compounds. Based on their in vitro cytotoxic activity and mostly their pattern of differential cellular sensitivity, two compounds described in this work have been selected by the NCI for further development. These compounds are currently being screened in animal models.
Authors:
G Gallant; R Salvador; H Dulude
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  13     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1993 Jan-Feb
Date Detail:
Created Date:  1993-05-18     Completed Date:  1993-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Affiliation:
Medicinal Chemistry Laboratory, Faculty of Pharmacy, University of Montréal, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology*
Drug Screening Assays, Antitumor
Humans
Neoplasms, Experimental / drug therapy*
Nitrosourea Compounds / pharmacology*
Tumor Cells, Cultured / drug effects
Urea / analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Nitrosourea Compounds; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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