Document Detail


In vitro cytotoxicity against human cancer cell lines during pulsed magnetic field exposure.
MedLine Citation:
PMID:  7979178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an in vitro cell growth assay, carboplatin potency against A-431 cells increased after a 1 hour PMF (pulsed magnetic field) exposure (calculated peak field 5.2 mTesla, with an average field strength of 0.525 mTeslarms; pulses rose for 120 microseconds and then abruptly fell to neutral, and were repeated at a rate of 100 or 250 pulses per second). This potentiating effect was not observed with cisplatin or daunomycin. When cytotoxicity against HT-29 cells was measured, PMF exposure potentiated both carboplatin and daunomycin, but again, not cisplatin. Both cell types exhibited increased growth when exposed only to PMF. Exposure to PMF consistently increased the cell growth of these cancer cell lines, while only some in vitro antineoplastic agents were potentiated by PMFs.
Authors:
C J Hannan; Y Liang; J D Allison; J R Searle
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  14     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1994 Jul-Aug
Date Detail:
Created Date:  1994-12-23     Completed Date:  1994-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1517-20     Citation Subset:  IM    
Affiliation:
Radiology Department, Medical College of Georgia, Augusta 30912.
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MeSH Terms
Descriptor/Qualifier:
Carboplatin / toxicity*
Cell Division / drug effects,  radiation effects
Cell Line
Cell Survival / drug effects,  radiation effects*
Cisplatin / toxicity*
Humans
Magnetics*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin; 41575-94-4/Carboplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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