| In vitro cytokine release assays: reducing the risk of adverse events in man. | |
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MedLine Citation:
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PMID: 22136053 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The induction of cytokine release is a common consequence of the administration of therapeutic antibodies and in most cases is either tolerated by the patient or can be managed clinically by the administration of corticosteroids. However, in 2006, the administration of TGN1412 to six patients in a Phase I trial resulted in a unprecedentedly high level of cytokine release, systemic organ failure and the hospitalization of the subjects. Whilst the path to failure in this incident was multifactorial, at least one contributing factor was the lack of a robust in vitro model that would allow the prediction of the in vivo activity of a therapeutic antibody. In this article we review the current 'state of the art' of in vitro cytokine release assays and explore potential future developments. |
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Authors:
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Christopher M Kirton; Daniel R Gliddon; Gregory Bannish; Gary P Bembridge; Lee A Coney |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioanalysis Volume: 3 ISSN: 1757-6199 ISO Abbreviation: Bioanalysis Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101512484 Medline TA: Bioanalysis Country: England |
Other Details:
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Languages: eng Pagination: 2657-63 Citation Subset: IM |
Affiliation:
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Huntingdon Life Sciences, Woolley Road, Alconbury, Cambridgeshire, PE28 4HS, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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