| In vitro corticosteroid: correlation response with primary open-angle glaucoma and ocular corticosteroid sensitivity. | |
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MedLine Citation:
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PMID: 1110208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The transformation of human peripheral blood lymphocytes can be inhibited by corticosteroid compounds. In an in vitro study of 100 patients with primary open-angle glaucoma and various degrees of ocular pressure responsiveness to corticosteroid testing, varying degrees of sensitivity to corticosteroid compounds existed systemically in the circulating lymphocyte. A high correlation exists between the level of corticosteroid sensitivity in the lymphocyte and in the eye. In vitro cellular systems may be useful in evaluating the molecular basis of the variability in corticosteroid response, and in understanding the pathogenesis of corticosteroid-induced ocular hypertension and primary open-angle glaucoma. |
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Authors:
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J F Bigger; P F Palmberg; H A Zink |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of ophthalmology Volume: 79 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-04-11 Completed Date: 1975-04-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 92-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Depression, Chemical Dexamethasone / pharmacology Dose-Response Relationship, Drug Glaucoma / physiopathology* Humans Hydrocortisone / blood Intraocular Pressure / drug effects* Lectins Lymphocyte Activation / drug effects Organophosphorus Compounds / pharmacology Prednisolone / analysis, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Lectins; 0/Organophosphorus Compounds; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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