Document Detail

In vitro conversion of androgen to estrogen in amphioxus gonadal tissues.
MedLine Citation:
PMID:  6541606     Owner:  NLM     Status:  MEDLINE    
The ability to convert androgen to estrogen (aromatization) is a constant feature of gonadal and neural tissues in all major vertebrate groups. In experiments reported here, the existence of this pathway was investigated in the protochordate amphioxus (Branchiostoma lanceolatum). Following incubation with [3H]19-hydroxyandrostenedione, gonadal homogenates contained authentic estrone and estradiol-17 beta, as determined by derivative formation and recrystallization to constant specific activity. Cephalic ("brain") and other segments were aromatase negative. The results indicate that a potential for estrogen biosynthesis in the gonads predates that in other tissues and arises prior to the evolution of true vertebrates.
G V Callard; J A Pudney; S L Kendall; R Reinboth
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  General and comparative endocrinology     Volume:  56     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-12-20     Completed Date:  1984-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
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MeSH Terms
Androstenedione / analogs & derivatives*,  metabolism
Aromatase / metabolism
Brain / metabolism
Chordata, Nonvertebrate / metabolism*
Estradiol / metabolism*
Estrone / metabolism*
Gonads / metabolism
Ovary / metabolism
Testis / metabolism
Grant Support
Reg. No./Substance:
50-28-2/Estradiol; 510-64-5/19-hydroxy-4-androstene-3,17-dione; 53-16-7/Estrone; 63-05-8/Androstenedione; EC

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