Document Detail

In vitro cisplatin effects on phagocyte functions.
MedLine Citation:
PMID:  4040125     Owner:  NLM     Status:  MEDLINE    
The effects of cis-diamminedichloroplatinum (II) (cisplatin), a drug used in cancer chemotherapy, on the oxidative metabolism, endocytosis, chemotaxis and exocytosis of guinea-pig polymorphonuclear leukocytes were studied. All these functions were negatively influenced, but the same effect (50% inhibition) was observed at different drug concentrations (3 X 10(-5) M for chemotaxis, 10(-4) M for O2 consumption by FMLP and beta-glucuronidase release, 10(-3) M for O2 consumption by PMA and for zymosan engulfment). The effects of the drug can be explained by its ability to bind to membrane proteins, essentially to -SH groups.
R Fumarulo; S Riccardi; R Pantaleo; M Coluccia; D Giordano; M Aresta
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  35     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-07     Completed Date:  1985-08-07     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  777-80     Citation Subset:  IM    
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MeSH Terms
Chemotaxis / drug effects
Cisplatin / pharmacology*
Cytochalasin B / pharmacology
Dose-Response Relationship, Drug
Endocytosis / drug effects
Exocytosis / drug effects
Glucuronidase / metabolism
Guinea Pigs
Neutrophils / drug effects*,  physiology
Oxygen Consumption / drug effects
Peritoneum / cytology
Phagocytosis / drug effects*
Reg. No./Substance:
14930-96-2/Cytochalasin B; 15663-27-1/Cisplatin; EC

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