Document Detail


In vitro circadian rhythms: imaging and electrophysiology.
MedLine Citation:
PMID:  21819387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vitro assays have localized circadian pacemakers to individual cells, revealed genetic determinants of rhythm generation, identified molecular players in cell-cell synchronization and determined physiological events regulated by circadian clocks. Although they allow strict control of experimental conditions and reduce the number of variables compared with in vivo studies, they also lack many of the conditions in which cellular circadian oscillators normally function. The present review highlights methods to study circadian timing in cultured mammalian cells and how they have shaped the hypothesis that all cells are capable of circadian rhythmicity.
Authors:
Christian Beaulé; Daniel Granados-Fuentes; Luciano Marpegan; Erik D Herzog
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Essays in biochemistry     Volume:  49     ISSN:  1744-1358     ISO Abbreviation:  Essays Biochem.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-08-08     Completed Date:  2011-11-29     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0043306     Medline TA:  Essays Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-17     Citation Subset:  IM    
Affiliation:
Department of Biology, Washington University in Saint Louis, MO 63130-4899, U.S.A.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Astrocytes / physiology*
Cell Line, Tumor
Cells, Cultured
Circadian Clocks / physiology
Circadian Rhythm / physiology*
Electrophysiological Phenomena
Humans
Molecular Imaging / methods*
Neurons / metabolism,  physiology*
Suprachiasmatic Nucleus / physiology*
Grant Support
ID/Acronym/Agency:
GM078993/GM/NIGMS NIH HHS; MH63104/MH/NIMH NIH HHS; R01 MH063104/MH/NIMH NIH HHS
Comments/Corrections

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