| In vitro chemosensitivity and radiosensitivity of an adriamycin-resistant subline of human small cell lung cancer cells. | |
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MedLine Citation:
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PMID: 3012966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using a cell line (SBC-3/ADM) of human small cell lung cancer, which is 30-fold more resistant to adriamycin than the parent cell line (SBC-3), the activity of a variety of anticancer agents was analyzed by soft agar clonogenic assay to search for a means of circumventing drug resistance. The SBC-3/ADM cells were markedly resistant to some anthracycline antibiotics in comparison with the SBC-3 cells: 28-fold for daunomycin, 26-fold for 4'-epiadriamycin, 18-fold for THP-adriamycin, and 8.4-fold for aclarubicin. However, the cells were as sensitive to mitoxantrone, one of the anthraquinone derivatives, as the parent cells. The cells were resistant to structurally or pharmacodynamically unrelated compounds such as vincristine, mitomycin C, and an active form of ifosfamide, whereas they were susceptible to cisplatin to some extent. The in vitro radiosensitivity of both cell lines was also evaluated, and they were found to be equally sensitive to X-ray. These results suggest that mitoxantrone and cisplatin may exert sufficient activity for small cell lung cancer which has acquired resistance to adriamycin, and that consolidative chest irradiation may be clinically useful after combination chemotherapy including adriamycin. |
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Authors:
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H Miyamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Okayama Volume: 40 ISSN: 0386-300X ISO Abbreviation: Acta Med. Okayama Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-06-27 Completed Date: 1986-06-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417611 Medline TA: Acta Med Okayama Country: JAPAN |
Other Details:
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Languages: eng Pagination: 75-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anthraquinones
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pharmacology Antineoplastic Agents / pharmacology Carcinoma, Small Cell / drug therapy*, pathology, radiotherapy Cell Line Cell Survival / drug effects, radiation effects Cisplatin / pharmacology Dose-Response Relationship, Drug Doxorubicin / pharmacology* Drug Resistance Humans Lung Neoplasms / drug therapy*, pathology, radiotherapy Mitoxantrone Tumor Stem Cell Assay |
| Chemical | |
Reg. No./Substance:
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0/Anthraquinones; 0/Antineoplastic Agents; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin; 65271-80-9/Mitoxantrone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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