| In vitro characterization of phosphatidylglyceroglycerol-based thermosensitive liposomes with encapsulated 1H MR T1-shortening gadodiamide. | |
| | |
MedLine Citation:
|
PMID: 18330933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Thermosensitive liposomes (TSL) with encapsulated proton (1H) magnetic resonance (MR) contrast agents have been proposed for noninvasive online temperature monitoring during tumor treatment using chemotherapy combined with hyperthermia (HT). The technique exploits the fact that water exchange between the TSL interior and exterior is increased and/or the encapsulated 1H MR contrast agent is released near the gel-to-liquid crystalline phase transition temperature (Tm) of TSL and thus shortens the 1H MR relaxation time of tissue. In this work, newly developed, phosphatidylglyceroglycerol (DPPGOG)-based TSL with encapsulated 1H MR longitudinal relaxation time (T1)-shortening gadodiamide (Gd-DTPA-BMA) were characterized in vitro by measuring the temperature dependence of the T1 of these gadodiamide-containing DPPGOG-TSL samples between 30 and 50 degrees C. The measurements revealed that the T1 nonlinearly slightly decreased with increasing temperature from 30 to 37 degrees C, mainly due to increased water exchange between the gadodiamide-containing DPPGOG-TSL interior and exterior with the exception of negligible gadodiamide release. This implies that gadodiamide-containing DPPGOG-TSL were stable at temperatures < or =37 degrees C, which was also confirmed by an independent stability study. From 37 to 44 degrees C, the T1 nonlinearly markedly decreased with increasing temperature since encapsulated gadodiamide was rapidly released. Above 44 degrees C, gadodiamide was completely released and the T1 was directly proportional to temperature while heated from 44 to 50 degrees C and cooled from 50 to 30 degrees C, respectively. Additionally, gadodiamide release was theoretically quantified and this calculated concentration was consistent with the actually released amount directly obtained from the cooling course of empty DPPGOG-TSL with completely released gadodiamide. |
| | |
Authors:
|
Tungte Wang; Martin Hossann; Herbert M Reinl; Michael Peller; Hansjoerg Eibl; Maximilian Reiser; Rolf D Issels; Lars H Lindner |
Related Documents
:
|
6094213 - Temperature-dependent development of ouabain action in isolated guinea pig heart: diffe... 16127243 - Augmentation of alpha1-adrenoceptor-mediated contraction by warming without increased p... 6203793 - Collagen in the egg shell membranes of the hen. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Contrast media & molecular imaging Volume: 3 ISSN: 1555-4317 ISO Abbreviation: Contrast Media Mol Imaging Publication Date: 2008 Jan-Feb |
Date Detail:
|
Created Date: 2008-03-17 Completed Date: 2008-06-17 Revised Date: 2010-10-29 |
Medline Journal Info:
|
Nlm Unique ID: 101286760 Medline TA: Contrast Media Mol Imaging Country: United States |
Other Details:
|
Languages: eng Pagination: 19-26 Citation Subset: IM |
Copyright Information:
|
(c) 2008 John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Internal Medicine III, University Hospital Grosshadern, University of Munich, Munich, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Contrast Media
/
chemistry* Drug Stability Gadolinium DTPA / chemistry* Hot Temperature Liposomes / chemistry* Magnetic Resonance Imaging / methods Phase Transition Phospholipids / chemistry* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Liposomes; 0/Phospholipids; 122795-43-1/gadodiamide; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: RNA expression microarray analysis in mouse prospermatogonia: identification of candidate epigenetic...
Next Document: H pylori recurrence after successful eradication.