| In vitro changes in gamma-aminobutyric acid output from the cerebral cortex induced by inhibitors of gamma-aminobutyric acid uptake and metabolism. | |
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MedLine Citation:
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PMID: 7086436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of inhibitors of gamma-aminobutyric acid (GABA) metabolism or uptake on GABA output from the cerebral cortex was studied by means of a collecting cup placed on the exposed cortex of rats anaesthetized with urethane. GABA was identified and quantified by a mass-fragmentographic method. Ethanolamine-O-sulphate (10(-2) M) applied directly on the cerebral cortex caused a long-lasting twofold increase in GABA output, whereas DL-2,4-diaminobutyric acid (5 X 10(-3) M) caused a sevenfold increase and beta-alanine was active. The results indicate that glial uptake has little effect on GABA inactivation in the cerebral cortex. The inhibition of neuronal uptake seems a more effective tool to increase GABA concentration in the synaptic cleft, and consequently also in GABA output, than the inhibition of GABA metabolism. |
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Authors:
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F Moroni; A Mulas; G Moneti; G Pepeu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurochemistry Volume: 39 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1982 Aug |
Date Detail:
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Created Date: 1982-08-26 Completed Date: 1982-08-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 582-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminobutyric Acids
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pharmacology* Animals Cerebral Cortex / drug effects, metabolism* Ethanolamines / pharmacology* Gas Chromatography-Mass Spectrometry Male Neuroglia / metabolism Neurons / metabolism Rats Rats, Inbred Strains gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Aminobutyric Acids; 0/Ethanolamines; 305-62-4/2,4-diaminobutyric acid; 56-12-2/gamma-Aminobutyric Acid; 926-39-6/ethanolamine O-sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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