Document Detail

In vitro cell transformation screening of 4 toluene diamine isomers.
MedLine Citation:
PMID:  7442705     Owner:  NLM     Status:  MEDLINE    
2,4-, 2,5-, 2,6- and 3,4-Toluene diamine (TDA) were tested for their ability to enhance the transformation of primary hamster embryo cells (HEC) by Simian adenovirus 7 (SA7) when administered either prior to or after virus inoculation and for their ability to transform secondary HEC. 2,4-TDA was inactive when given prior to SA7, but active if given after. 2,5-TDA was active in both protocols. 2,6-TDA was marginally active if administered before virus and was the most active of the isomers when administered after virus. 3,4-TDA was the most active compound when added prior to SA7, and was also active when given after virus. All the isomers were capable of producing good dose--responses and absolute increases in the number of virus-transformed foci per dish in one or both of the experimental regimens. Each isomer chemically transformed secondary HEC but good dose--responses were rare, and none of the chemicals were active in more than 50% of the 5 or 6 separate tests performed on each.
E J Greene; M A Friedman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  79     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-02-26     Completed Date:  1981-02-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  363-75     Citation Subset:  IM    
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MeSH Terms
Adenoviruses, Simian
Cell Transformation, Viral / drug effects*
Cells, Cultured
Dose-Response Relationship, Drug
Embryo, Mammalian / cytology
Phenylenediamines / pharmacology*
Reg. No./Substance:

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