Document Detail


In vitro cell response of Treponema pallidum-infected rabbits. II. Inhibition of lymphocyte response to phytohaemagglutinin by serum of T. pallidum-infected rabbits.
MedLine Citation:
PMID:  589866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum inhibitors of lymphocyte response to PHA were found in T. pallidum-infected rabbits. The humoral inhibitors could be detected as early as 10 days after infection and persisted for at least 6 months. The factors also suppressed the allogeneic lymphocyte response. Control, or normal, rabbit sera likewise contain serum inhibitors, but in much lower concentration. The detection of the humoral inhibitors depended on the susceptibility of the indicator lymphocytes. Cells of some rabbits were more sensitive to the inhibitors than others. In addition to serum inhibitors, lymphocytes of T. pallidum-infected animals seem to be impaired and responded to PHA less vigorously than cells of normal rabbits. The inhibitory activity is most likely the result of a complex group of substances with different physicochemical characteristics; some pre-exist and others are newly formed after infection. Problems associated with the detection of such inhibitors are discussed.
Authors:
V Wicher; K Wicher
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  29     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  487-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood
Dialysis
Hot Temperature
Immunosuppression
Kinetics
Lymphocyte Activation*
Male
Rabbits
Syphilis / immunology*
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