Document Detail

In vitro cardiac function in early sepsis.
MedLine Citation:
PMID:  2212867     Owner:  NLM     Status:  MEDLINE    
The involvement of the myocardium in the injury resulting from bacteremia has been somewhat controversial. Recently, some investigators have suggested that the transition from an early stage of sepsis, in which the cardiovascular system is stable and mortality is relatively low, to the late or preterminal stage of sepsis is a result of cardiac dysfunction. Here, however, data are presented to show that contractile defects and loss of myocardial reserve occur even early during a septic episode, i.e., at a time when cardiac output is elevated or normal. Efforts to determine the mechanism of the cardiac dysfunction are described. These entail studies of whole heart performance under conditions of varying the calcium availability for contraction and assessment of subcellular organelle function. The data indicate that calcium dyshomeostasis may at least partially contribute to the cardiac dysfunction of sepsis. The in vivo adequacy of cardiac function probably results from the capacity of the myocardium in early sepsis to respond to catecholamine support of chronotropy and inotropy.
K H McDonough; E C Burke; L W Smith
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of medicine     Volume:  21     ISSN:  0025-7850     ISO Abbreviation:  J Med     Publication Date:  1990  
Date Detail:
Created Date:  1990-11-19     Completed Date:  1990-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505566     Medline TA:  J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  27-49     Citation Subset:  IM    
Department of Physiology, Louisiana State University Medical Center, New Orleans.
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MeSH Terms
Bacterial Infections / pathology,  physiopathology*
Catecholamines / physiology
Heart / drug effects,  physiopathology*
Isoproterenol / pharmacology
Myocardial Contraction
Myocardium / pathology,  ultrastructure
Organelles / physiology
Sepsis / pathology,  physiopathology
Reg. No./Substance:
0/Catecholamines; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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