Document Detail

In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps.
MedLine Citation:
PMID:  22760951     Owner:  NLM     Status:  MEDLINE    
Nanomaterials increasingly are playing a role in society for uses ranging from biomedicine to microelectronics; however, pharmacokinetic studies, which will be necessary for human health risk assessments, are limited. Currently the most widely used nanoparticle in consumer products is silver (Ag). The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag-citrate and Ag-silica, in the isolated perfused porcine skin flap (IPPSF). IPPSFs were perfused for 4 h with 0.84 µg ml(-1) Ag-citrate or 0.48 µg ml(-1) Ag-silica followed by a 4-h perfusion with media only during a washout phase. Arterial and venous concentrations of Ag were measured in the media by inductively coupled plasma optical emission spectrometry (ICP-OES). Venous concentrations of Ag for both types of nanoparticles were best fit with a two compartment model. The normalized volumes of distribution estimated from the noncompartmental analysis of the venous concentrations indicated distribution of Ag greater than the vascular space; however, because total Ag was measured, the extravascular distribution could be attributed to diffusion of Ag ions. The estimated clearance for both types of Ag nanoparticles was 1 ml min(-1) , which was equal to the flap perfusion rate, indicating no detectable elimination of Ag from the system. Four hours after infusion of the Ag nanoparticles, the recovery of Ag in the venous effluent was 90 ± 5.0% and 87 ± 22% of the infused Ag for Ag-citrate and Ag-silica, respectively.
Teresa L Leavens; Nancy A Monteiro-Riviere; Alfred O Inman; James D Brooks; Steven J Oldenburg; Jim E Riviere
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-04
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  32     ISSN:  1099-1263     ISO Abbreviation:  J Appl Toxicol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-09-26     Completed Date:  2013-03-07     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  913-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
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MeSH Terms
Metal Nanoparticles / chemistry*
Nanoparticles / chemistry
Silver / chemistry,  pharmacokinetics*
Skin / metabolism*
Swine / metabolism*
Tissue Distribution
Grant Support
Reg. No./Substance:

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