Document Detail

In vitro biocorrosion of Ti-6Al-4V implant alloy by a mouse macrophage cell line.
MedLine Citation:
PMID:  14986326     Owner:  NLM     Status:  MEDLINE    
Corrosion of implant alloys releasing metal ions has the potential to cause adverse tissue reactions and implant failure. We hypothesized that macrophage cells and their released reactive chemical species (RCS) affect the alloy's corrosion properties. A custom cell culture corrosion box was used to evaluate how cell culture medium, macrophage cells and RCS altered the Ti-6Al-4V corrosion behaviors in 72 h and how corrosion products affected the cells. There was no difference in the charge transfer in the presence (75.2 +/- 17.7 mC) and absence (62.3 +/- 18.8 mC) of cells. The alloy had the lowest charge transfer (28.2 +/- 4.1 mC) and metal ion release (Ti < 10 ppb, V < 2 ppb) with activated cells (releasing RCS) compared with the other two conditions. This was attributed to an enhancement of the surface oxides by RCS. Metal ion release was very low (Ti < 20 ppb, V < 10 ppb) with nonactivated cells and did not change cell morphology, viability, and NO and ATP release compared with controls. However, IL-1beta released from the activated cells and the proliferation of nonactivated cells were greater on the alloy than the controls. In summary, macrophage cells and RCS reduced the corrosion of Ti-6Al-4V alloys as hypothesized. These data are important in understanding host tissue-material interactions.
Hsin-Yi Lin; Joel D Bumgardner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  68     ISSN:  1549-3296     ISO Abbreviation:  -     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-26     Completed Date:  2004-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  717-24     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 717-724, 2004
Biomedical Engineering Program, Department of Agriculture and Biological Engineering, Mail stop 9632, Mississippi State University, Mississippi State, Mississippi 39762, USA.
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MeSH Terms
Macrophages / metabolism*
Prostheses and Implants*
Titanium / metabolism*
Reg. No./Substance:
12743-70-3/titanium alloy (TiAl6V4); 7440-32-6/Titanium

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