| In vitro approach to 'uremic cardiomyopathy'. | |
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MedLine Citation:
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PMID: 8289989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular complications determine the prognosis of patients with chronic renal failure. The contribution of compounds retained during uremia to specific myocardial lesions is controversial. We investigated the contractility of spontaneously beating mouse cardiac myocytes in culture under perfusion with sera derived from patients on maintenance hemodialysis and test solutions containing possible toxins. Cellular contractility under defined environmental conditions is determined by a computer-assisted digital image analysis. 'Uremic sera', creatinine, urea, and combinations of these compounds reduce inotropy of the cultured heart cells, induce arrhythmias or asynchronies in a concentration-dependent manner. We propose the myocyte perfusion technique as an in vitro approach to identify cardiotoxins in the body fluids of chronically uremic patients. |
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Authors:
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D Weisensee; I Löw-Friedrich; M Riehle; J Bereiter-Hahn; W Schoeppe |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nephron Volume: 65 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1993 |
Date Detail:
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Created Date: 1994-02-22 Completed Date: 1994-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 392-400 Citation Subset: IM |
Affiliation:
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Cinematic Cell Research Group, Hospital of the Johann Wolfgang Goethe-University, Frankfurt am Main, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomyopathies / etiology* Cells, Cultured Creatinine / pharmacology Humans Mice Models, Cardiovascular Myocardial Contraction / drug effects Myocardium / cytology Perfusion Toxins, Biological / metabolism, toxicity Urea / pharmacology Uremia / complications*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Toxins, Biological; 57-13-6/Urea; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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