Document Detail

In vitro antitumor activity of triterpenes from Ceriops tagal.
MedLine Citation:
PMID:  18075884     Owner:  NLM     Status:  MEDLINE    
The embryo of Ceriops tagal was extracted with 95% ethanol at room temperature, and four triterpenes (1-4) were separated from this extract. For the first time these triterpenes were the separated from this plant. Compounds (1-4) were tested in vitro for antitumor activity against three cell lines (human liver cancer cell (H-7402), human B-lymphoblastoid cell (Raji), and human cervical carcinoma cell (Hela)). Compounds 1 and 3 were effective to inhibit cell proliferation and growth of H-7402 and Hela, the IC(50) of them on H-7402 were 14.42 microg mL(-1) and 9.97 microg mL(-1), and the IC(50) of them on Hela were 11.84 microg mL(-1) and 11.32 microg mL(-1). All compounds 1-4 were not effective to inhibit cell proliferation and growth of Raji. The effects of compound 4 on inhibiting proliferation and growth of these three cancer cells was also not obvious.
Lei He; You-Shao Wang; Qing-Ji Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product research     Volume:  21     ISSN:  1478-6419     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-13     Completed Date:  2008-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1228-33     Citation Subset:  IM    
Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academic of Sciences, Guangzhou 510301, China.
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MeSH Terms
Antineoplastic Agents / chemistry,  isolation & purification,  pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Hela Cells
Molecular Structure
Plant Extracts / chemistry,  isolation & purification,  pharmacology
Plants, Medicinal / chemistry
Rhizophoraceae / chemistry*
Triterpenes / chemistry,  isolation & purification,  pharmacology*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Plant Extracts; 0/Triterpenes

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