Document Detail


In vitro antiprotozoal activity of some xanthones isolated from the roots of Andrographis paniculata.
MedLine Citation:
PMID:  18683849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four xanthones isolated from the roots of Andrographis paniculata were tested in vitro for antiprotozoal activity against Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania infantum. Compound TDR13011 (1,2-dihydroxy-6,8-dimethoxy-xanthone) showed good activity against T. b. brucei and L. infantum with a 50% inhibitory concentration (IC50) of 4.6 microg/ml and 8 microg/ml respectively. Xanthones from the roots of Andrographis paniculata exhibited promising anti-protozoal activity and these compounds could be chemically modified to obtain a more potent product.
Authors:
Virendra K Dua; Gaurav Verma; A P Dash
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  23     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-29     Completed Date:  2009-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  126-8     Citation Subset:  IM    
Copyright Information:
Copyright 2008 John Wiley & Sons, Ltd.
Affiliation:
National Institute of Malaria Research, Field Unit, Sector III, BHEL, Hardwar 249 403, India. vkdua51@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Andrographis / chemistry*
Animals
Antiprotozoal Agents / isolation & purification,  pharmacology*
Inhibitory Concentration 50
Leishmania infantum / drug effects
Molecular Structure
Parasitic Sensitivity Tests
Plant Roots / chemistry
Trypanosoma brucei brucei / drug effects
Trypanosoma cruzi / drug effects
Xanthones / isolation & purification,  pharmacology*
Chemical
Reg. No./Substance:
0/2-dihydroxy-6,8-dimethoxy-xanthone; 0/Antiprotozoal Agents; 0/Xanthones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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