Document Detail


In vitro antiproliferative effect of six Salvia species on human tumor cell lines.
MedLine Citation:
PMID:  16676297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to examine the in vitro antiproliferative activity of the methanol crude extracts of six Salvia species: Salvia dominica L. leaves, Salvia lanigera Desf. aerial parts, Salvia menthaefolia Ten. roots, Salvia palaestina Benth. aerial parts, Salvia sclarea L. roots and Salvia spinosa L. aerial parts. Extracts were screened for their possible antitumoral activity by MTT test on nine human cancer cell lines: glioblastoma (DBTRG-05MG, T98G, U-87MG), colorectal adenocarcinoma (WiDr and HT-29), prostate adenocarcinoma (MDA Pca2b), choriocarcinoma (JEG-3), endometrium adenocarcinoma (HEC-1A) and B lymphoblast (CIR). IC(50) values were determined for only five extracts and ranged from 90 to 400 microg/mL approximately. Salvia menthaefolia extract exhibited marked antiproliferative activity against all tumor cell lines showing lower IC(50) values, while S. spinosa, S. sclarea and S. dominica extracts showed a degree cytotoxic activity dependent on the cell line type. Finally S. palaestina extract revealed a moderate antiproliferative effect only against three cell lines. Salvia lanigera extract displayed toxic activity at all concentrations tested. The results strengthen the evidence that the genus Salvia could be considered a natural resource of potential antitumor agents.
Authors:
Giovina Fiore; Cristina Nencini; Federica Cavallo; Anna Capasso; Ammar Bader; Giorgio Giorgi; Lucia Micheli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  20     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-28     Completed Date:  2006-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  701-3     Citation Subset:  IM    
Affiliation:
Department of Pharmacology 'Giorgio Segre', University of Siena, Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects*
Cell Survival / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Phytotherapy*
Plant Extracts / pharmacology*
Salvia*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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