| In vitro antimicrobial activity of some cyclic hydroxamic acids and related lactams. | |
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MedLine Citation:
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PMID: 400828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Against Enterobacter aerogenes 13048, Serratia marcescens 13880, Klebsiella pneumoniae 10031, Pseudomonas aeruginosa 10145, Escherichia coli 9723, Lactobacillus casei 7469, Lactobacillus plantarum 8014, Leuconostoc dextranicum 8086, and Streptococcus faecalis 8043, the mean minimal inhibitory concentrations of three cyclic hydroxamic acids, 3-amino-3,4-dihydro-1-hydroxycarbostyril, the 6-chloro analog, and the 7-chloro analog, were 0.6, 0.6, and 0.2 micrograms/ml, and those of the corresponding lactams, 3-amino-3,4-dihydrocarbostyril, the 6-chloro analog, and the 7-chloro analog, were 60, 60, and 6 micrograms/ml, respectively. Under the same assay conditions the mean minimal inhibitory concentrations of chloramphenicol and kanamycin were both 2 micrograms/ml. In addition, the cyclic hydroxamic acids but not the lactams inhibited the growth of Candida albicans at minimal inhibitory concentrations ranging from 20 to 200 micrograms/ml, at pH 7, as compared with that of amphotericin B, at 2 micrograms/ml. |
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Authors:
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A L Davis; K L Hulme; G T Wilson; T J McCord |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 13 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 1978 Mar |
Date Detail:
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Created Date: 1986-10-30 Completed Date: 1986-10-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 542-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology* Bacteria / drug effects Candida albicans / drug effects Hydroxamic Acids / pharmacology* Lactams / pharmacology* Microbial Sensitivity Tests |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Hydroxamic Acids; 0/Lactams |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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