| In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India. | |
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MedLine Citation:
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PMID: 11693874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an attempt to search for new antimalarial drugs, we studied plants used by traditional healers of southwest India to treat malaria. Aqueous and organic solvent extracts obtained from specific parts of the plants Swertia chirata, Carica papaya, and Citrus sinensis were tested on malaria strain Plasmodium falciparum FCK 2 in vitro. The temperatures of extraction were the same as that used by the traditional healers in their plant preparations. Visual evaluation of the antimalarial activity of the plant extracts on thin blood smears was followed by quantification of the activity by use of [35S]-methionine incorporation into parasite proteins to determine the value that inhibits 50% (IC50). Among the 3 plants tested, 2 had significant inhibitory effect on P. falciparum in vitro. |
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Authors:
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G P Bhat; N Surolia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 65 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-11-05 Completed Date: 2001-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 304-8 Citation Subset: AIM; IM |
Affiliation:
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Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, Karnataka State, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimalarials / pharmacology, therapeutic use* Carica Citrus Drug Resistance Humans India Lethal Dose 50 Malaria, Falciparum / drug therapy* Parasitic Sensitivity Tests Phytotherapy* Plant Extracts / pharmacology, therapeutic use* Plasmodium falciparum / drug effects*, growth & development Swertia |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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