Document Detail


In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India.
MedLine Citation:
PMID:  11693874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an attempt to search for new antimalarial drugs, we studied plants used by traditional healers of southwest India to treat malaria. Aqueous and organic solvent extracts obtained from specific parts of the plants Swertia chirata, Carica papaya, and Citrus sinensis were tested on malaria strain Plasmodium falciparum FCK 2 in vitro. The temperatures of extraction were the same as that used by the traditional healers in their plant preparations. Visual evaluation of the antimalarial activity of the plant extracts on thin blood smears was followed by quantification of the activity by use of [35S]-methionine incorporation into parasite proteins to determine the value that inhibits 50% (IC50). Among the 3 plants tested, 2 had significant inhibitory effect on P. falciparum in vitro.
Authors:
G P Bhat; N Surolia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  65     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-05     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  304-8     Citation Subset:  AIM; IM    
Affiliation:
Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, Karnataka State, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimalarials / pharmacology,  therapeutic use*
Carica
Citrus
Drug Resistance
Humans
India
Lethal Dose 50
Malaria, Falciparum / drug therapy*
Parasitic Sensitivity Tests
Phytotherapy*
Plant Extracts / pharmacology,  therapeutic use*
Plasmodium falciparum / drug effects*,  growth & development
Swertia
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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