Document Detail

In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae).
MedLine Citation:
PMID:  19540316     Owner:  NLM     Status:  MEDLINE    
Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani, with an IC(50) value of 45 microg/mL, while GPE presented an IC(50) value of 49 microg/mL. Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC(50) values of 3.7 microg/mL and 7.0 microg/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC(50) values (about 20 microg/mL), while Hautriwaic acid lactone led to an IC(50) value of 0.8 microg/mL (D6 clone).
A A da Silva Filho; D O Resende; M J Fukui; F F Santos; P M Pauletti; W R Cunha; M L A Silva; L E Greg??rio; J K Bastos; N P D Nanayakkara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-18
Journal Detail:
Title:  Fitoterapia     Volume:  80     ISSN:  1873-6971     ISO Abbreviation:  Fitoterapia     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  16930290R     Medline TA:  Fitoterapia     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  478-82     Citation Subset:  IM    
Laborat??rio de Produtos Naturais, N??cleo de Pesquisa em Ci??ncias Exatas e Tecnol??gicas, Universidade de Franca, Av. Dr. Armando Sales de Oliveira, 201, CEP 14404-600, Franca, SP, Brazil.
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MeSH Terms
Antimalarials / adverse effects,  isolation & purification,  pharmacology*
Baccharis / chemistry*
Cercopithecus aethiops
Leishmania donovani / drug effects
Microbial Sensitivity Tests
Parasitic Sensitivity Tests
Phenols / adverse effects,  isolation & purification,  pharmacology*
Plant Extracts / adverse effects,  chemistry,  pharmacology*
Plant Leaves
Plasmodium falciparum / drug effects
Triterpenes / adverse effects,  isolation & purification,  pharmacology*
Trypanocidal Agents / adverse effects,  isolation & purification,  pharmacology*
Vero Cells
Reg. No./Substance:
0/Antimalarials; 0/Phenols; 0/Plant Extracts; 0/Triterpenes; 0/Trypanocidal Agents; 9009-62-5/Propolis

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