Document Detail


In vitro antifungal activity of omoconazole nitrate, a novel imidazone antimycotic drug, against clinical isolates from patients with cutaneous mycosis
MedLine Citation:
PMID:  9053537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vitro antifungal activities of omoconazole nitrate (OMZ), a novel antifungal imidazole antimycotic drug, are examined against clinical isolates obtained from patients with cutaneous mycosis and its activity was compared with that of bifonazole (BFZ). The clinical isolates tested were 70 of dermatophytes including Trichophyton rubrum (47 isolates), T. mentagrophytes (22 isolates), Microsporum gypseum (1 isolate), and 27 isolates of Candida albicans. MIC values of OMZ to dermatophytes distributed in a range of < or = 0.04 to 0.63 microgram/ml were similar to those of BFZ (< or = 0.04 to 1.25 micrograms/ml). MIC values of OMZ to C. albicans were in a range of 0.16 to 2.5 micrograms/ml indicating that OMZ had more potent activities than BFZ (1.25 to 5 micrograms/ml). These results showed that in vitro antifungal activities of OMZ against clinical isolates of dermatophytes and C. albicans were greater than or similar to those of BFZ.
Authors:
K Uchida; T Itoyama; H Yamaguchi
Publication Detail:
Type:  Comparative Study; English Abstract; Journal Article    
Journal Detail:
Title:  The Japanese journal of antibiotics     Volume:  49     ISSN:  0368-2781     ISO Abbreviation:  Jpn J Antibiot     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-03-10     Completed Date:  1997-03-10     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0154402     Medline TA:  Jpn J Antibiot     Country:  JAPAN    
Other Details:
Languages:  jpn     Pagination:  818-23     Citation Subset:  IM    
Affiliation:
Teikyo University Institute of Medical Mycology.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / pharmacology*
Dermatomycoses / microbiology*
Drug Resistance, Microbial
Fungi / drug effects*,  isolation & purification*
Humans
Imidazoles / pharmacology*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Imidazoles; 60628-96-8/bifonazole; 74512-12-2/omoconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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