| In vitro antifungal activities of longan (Dimocarpus longan Lour.) seed extract. | |
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MedLine Citation:
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PMID: 22245574 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Longan, Dimocarpus longan Lour., contains polyphenolic compounds which exhibit several pharmacological properties. This study aims to evaluate antifungal activities of longan fruit extract in comparison to its active compounds. The results showed that longan seed exhibited antifungal activity against the opportunistic yeasts (Candida species and Cryptococcus neoformans). In contrast, longan pulp and whole fruit did not demonstrate any inhibitory effects. Ellagic acid showed the most potent antifungal activity followed by corilagin and gallic acid, respectively. Ellagic acid inhibited Candida parapsilosis and C. neoformans more effectively than Candida krusei and also some Candida albicans clinical strains. Baidam cultivar possessed higher antifungal activity (MIC=500-4000μg/ml) as it contained higher contents of ellagic acid and gallic acid than Edor (MIC=1000-8000μg/ml). For antibacterial activity, only corilagin and gallic acid possessed weak to moderate inhibitory effects against Staphylococcus aureus and Streptococcus mutans, respectively. Longan seed was then applied in the oral care products. Longan effervescent granule (5% extract) significantly reduced adhesion of C. albicans to acrylic strips. Mouthwash containing 0.5% extract exhibited good antifungal activity compared to a commercial product. These findings indicated that longan seed extract and its polyphenolic compounds can be used as an antifungal agent in oral care products for the treatment of opportunistic yeast infection. |
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Authors:
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Nuchanart Rangkadilok; Songsak Tongchusak; Rachasak Boonhok; Sansanee C Chaiyaroj; Varaporn B Junyaprasert; Waranun Buajeeb; Jaratluck Akanimanee; Thida Raksasuk; Theeralaksna Suddhasthira; Jutamaad Satayavivad |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-8 |
Journal Detail:
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Title: Fitoterapia Volume: - ISSN: 1873-6971 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Laboratory of Pharmacology, Chulabhorn Research Institute (CRI), Kamphaengphet 6 Road, Laksi, Bangkok 10210, Thailand; Environmental Toxicology Program, Chulabhorn Graduate Institute, Kamphaengphet 6 Road, Laksi, Bangkok 10210, Thailand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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