Document Detail

In vitro antibacterial activity of cefotaxime and desacetylcefotaxime, alone or in combination, against gram-positive cocci.
MedLine Citation:
PMID:  2101779     Owner:  NLM     Status:  MEDLINE    
The in vitro activity of cefotaxime and desacetylcefotaxime against Staphylococcus aureus, Staph. epidermidis and Streptococcus pyogenes was investigated. Synergy studies were performed using time-kill curves and the chequerboard test. The time-kill curves were performed on five strains each of Staph. aureus, Staph. epidermidis and Strep. pyogenes; cefotaxime and desacetylcefotaxime were tested alone or in combination at MIC and sub-MIC values. The chequerboard test was performed in microtitre plates on ten strains each of Staph. aureus, Staph. epidermidis and Strep. pyogenes: the results were interpreted by the fractional inhibitory concentration index. In some cases both methods showed synergistic interaction against the staphylococci tested. Indifference was observed against Strep. pyogenes.
M Cruciani; A Navarra; G Di Perri; M C Danzi; E Concia; D Bassetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  16     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1990  
Date Detail:
Created Date:  1991-09-19     Completed Date:  1991-09-19     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  565-8     Citation Subset:  IM    
Institute of Infectious Diseases, University of Verona, Italy.
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MeSH Terms
Cefotaxime / administration & dosage,  analogs & derivatives*,  pharmacology*
Ceftazidime / pharmacology
Ceftriaxone / pharmacology
Dose-Response Relationship, Drug
Drug Therapy, Combination
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects*
Staphylococcus epidermidis / drug effects*
Streptococcus pyogenes / drug effects*
Reg. No./Substance:
63527-52-6/Cefotaxime; 66340-28-1/desacetylcefotaxime; 73384-59-5/Ceftriaxone; 78439-06-2/Ceftazidime

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