Document Detail


In vitro antibacterial activity of cefotaxime and desacetylcefotaxime, alone or in combination, against gram-positive cocci.
MedLine Citation:
PMID:  2101779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro activity of cefotaxime and desacetylcefotaxime against Staphylococcus aureus, Staph. epidermidis and Streptococcus pyogenes was investigated. Synergy studies were performed using time-kill curves and the chequerboard test. The time-kill curves were performed on five strains each of Staph. aureus, Staph. epidermidis and Strep. pyogenes; cefotaxime and desacetylcefotaxime were tested alone or in combination at MIC and sub-MIC values. The chequerboard test was performed in microtitre plates on ten strains each of Staph. aureus, Staph. epidermidis and Strep. pyogenes: the results were interpreted by the fractional inhibitory concentration index. In some cases both methods showed synergistic interaction against the staphylococci tested. Indifference was observed against Strep. pyogenes.
Authors:
M Cruciani; A Navarra; G Di Perri; M C Danzi; E Concia; D Bassetti
Related Documents :
20108109 - Is nasal carriage of staphylococcus aureus the main acquisition pathway for surgical-si...
20606069 - Inhibition of antibiotic-resistant staphylococcus aureus by the broad-spectrum dihydrof...
3949699 - Evaluation of an improved mpn medium for recovery of stressed and nonstressed staphyloc...
20829609 - Nuclease expression by staphylococcus aureus facilitates escape from neutrophil extrace...
16569879 - Autolytic properties of glycopeptide-intermediate staphylococcus aureus mu50.
2913039 - Staphylococcus intermedius in canine gingiva and canine-inflicted human wound infection...
7592359 - Chea, chew, and chey are required for chemotaxis to oxygen and sugars of the phosphotra...
19618289 - Halobacillus hunanensis sp. nov., a moderately halophilic bacterium isolated from a sub...
22708369 - Phagocytosis of neutrophils in rabbits infected with antigenic variants of rhd (rabbit ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  16     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1990  
Date Detail:
Created Date:  1991-09-19     Completed Date:  1991-09-19     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  565-8     Citation Subset:  IM    
Affiliation:
Institute of Infectious Diseases, University of Verona, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cefotaxime / administration & dosage,  analogs & derivatives*,  pharmacology*
Ceftazidime / pharmacology
Ceftriaxone / pharmacology
Dose-Response Relationship, Drug
Drug Therapy, Combination
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects*
Staphylococcus epidermidis / drug effects*
Streptococcus pyogenes / drug effects*
Chemical
Reg. No./Substance:
63527-52-6/Cefotaxime; 66340-28-1/desacetylcefotaxime; 73384-59-5/Ceftriaxone; 78439-06-2/Ceftazidime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CTX and its desacetyl derivative (des-CTX): interaction with some representative beta-lactamases and...
Next Document:  Pharmacokinetic study of neostigmine after intranasal and intravenous administration in the guinea p...