| In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants. | |
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MedLine Citation:
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PMID: 22011769 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The in vitro anti-inflammatory effects of seven known lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were evaluated through the inhibition of COX-1, COX-2, 5-LOX and the aggregation of rabbit platelets induced by PAF, AA and ADP. (+)-de-4"-O--methylmagnolin 4 was found to be a potent COX-2/5-LOX dual inhibitor and PAF-antagonist (COX-2 IC50 2.27 µM; 5-LOX IC50 5.05 µM; PAF IC50 2.51 µM). However, all compounds exhibited an activity at different levels, indicating good anti-inflammatory properties to be considered in further structural optimization studies. |
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Authors:
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Ericsson D Coy-Barrera; Luis E Cuca-Suarez |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-21 |
Journal Detail:
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Title: Anais da Academia Brasileira de Ciencias Volume: - ISSN: 1678-2690 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503280 Medline TA: An Acad Bras Cienc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratorio de Investigación en Productos Naturales Vegetales, Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá D.C, Colombia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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