| In vitro anti-herpes simplex viruses and anti-adenoviruses activity of twelve traditionally used medicinal plants in Taiwan. | |
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MedLine Citation:
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PMID: 14600409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As an effort to search for new antiviral agents from traditional medicine, the hot water (HW) extract of twelve traditionally used medicinal plants in Taiwan was evaluated for their in vitro anti-herpes simplex viruses (HSV; including HSV-1 and HSV-2) and anti-adenoviruses (ADV; including ADV-3, ADV-8 and ADV-11) activities with a XTT-based colorimetric assay. Results showed that the tested HW extracts exhibited anti-HSV and anti-ADV activities at different magnitudes of potency. Among the twelve medicinal plants, Boussingaultia gracilis var. pseudobaselloides (Basellaceae) and Serissa japonica (Rubiaceae) possessed broad spectrum of antiviral activity. Ardisia squamulosa (Myrsinaceae) and Artemisai princeps var. orientalis (Compositae) were more effective in inhibiting ADV-8 replication than the other four viruses. Cell cytotoxic assay demonstrated that all tested HW extracts had CC50 values higher than their EC50 values. It was concluded that the twelve traditionally used medicinal plants in Taiwan possessed antiviral activity, and some of them merit further investigation. |
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Authors:
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Lien-Chai Chiang; Hua-Yew Cheng; Mei-Chi Liu; Wen Chiang; Chun-Ching Lin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 26 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-05 Completed Date: 2004-06-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 1600-4 Citation Subset: IM |
Affiliation:
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Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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drug effects*,
growth & development Antiviral Agents / isolation & purification, pharmacology* Cell Line, Tumor Drug Evaluation, Preclinical / methods Humans Plant Extracts / isolation & purification, pharmacology Plant Leaves Plant Stems Plants, Medicinal* Simplexvirus / drug effects*, growth & development Taiwan |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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