| In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria. | |
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MedLine Citation:
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PMID: 17926328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In early dental plaque formation, oral primary colonizers such as Streptococcus mutans, Streptococcus sanguis and Actinomyces viscosus are initially attached to the pellicle-coated tooth surface to form a biofilm. The study aimed to determine the efficacy of macelignan, isolated from nutmeg (Myristica fragrans Houtt.), in removing each single oral primary biofilm in vitro on a polystyrene 96-well microtiter plate. Four biofilm growth phases (4, 12, 20 and 24 h) were evaluated in this study after treatment with macelignan at various concentrations (0.2, 2 and 10 microg/mL) and exposure times (5, 10 and 30 min). Anti-biofilm activity of macelignan was measured as the percentage of the remaining biofilm absorbance after macelignan treatment in comparison with the untreated control. At 24 h of biofilm growth, S. mutans, A. viscosus and S. sanguis biofilms were reduced by up to 30%, 30% and 38%, respectively, after treatment with 10 microg/mL macelignan for 5 min. Increasing the treatment time to 30 min resulted in a reduction of more than 50% of each of the single primary biofilms. The results indicate that macelignan is a potent natural anti-biofilm agent against oral primary colonizers. |
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Authors:
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; Yaya Rukayadi; Kyu-Hoi Kim; Jae-Kwan Hwang |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 22 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-05 Completed Date: 2008-12-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 308-12 Citation Subset: IM |
Affiliation:
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Department of Biotechnology, Yonsei University, Seoul 120-749, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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pharmacology Biofilms / drug effects* Cariostatic Agents / isolation & purification, pharmacology* Chlorhexidine / analogs & derivatives, pharmacology Dental Caries / prevention & control Gram-Positive Bacteria / drug effects*, growth & development Lignans / chemistry, pharmacology* Myristica fragrans / chemistry* Phytotherapy Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Cariostatic Agents; 0/Lignans; 0/macelignan; 18472-51-0/chlorhexidine gluconate; 55-56-1/Chlorhexidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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