Document Detail


In vitro anti-Malassezia activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb.
MedLine Citation:
PMID:  17257249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: This study aimed at investigating the anti-Malassezia activity of xanthorrhizol (XTZ) isolated from Curcuma xanthorrhiza Roxb. against Malassezia furfur ATCC 14521 and Malassezia pachydermatis ATCC 14522. METHODS AND RESULTS: The in vitro susceptibility tests for XTZ were carried out in terms of minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), using broth microdilution method with endpoint after 48 h. Time-kill curves were determined at concentrations ranging from 0 to 25 microg ml(-1). The MIC values of XTZ against M. furfur and M. pachydermatis were 1.25 and 0.25 mug ml(-1), respectively. The MFC of XTZ was 5 microg ml(-1) for M. furfur and 2.5 microg ml(-1) for M. pachydermatis. Time-kill curves demonstrated that treatment with 25 microg ml(-1) of XTZ for 5 h was able to kill 100% of M. furfur, while 20 microg ml(-1) of XTZ for 15 min killed M. pachydermatis completely. CONCLUSION: XTZ shows potential as an anti-Malassezia agent for inhibiting the growth of M. furfur ATCC 14521 and M. pachydermatis ATCC 14522 in vitro. SIGNIFICANCE AND IMPACT OF THE STUDY: XTZ may be a useful alternative for treating Malassezia-associated diseases.
Authors:
Y Rukayadi; J-K Hwang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Letters in applied microbiology     Volume:  44     ISSN:  0266-8254     ISO Abbreviation:  Lett. Appl. Microbiol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510094     Medline TA:  Lett Appl Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  126-30     Citation Subset:  IM    
Affiliation:
Department of Biotechnology & Bioproducts Research Center (BRC), Yonsei University, Seoul 120-739, Korea.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / pharmacology*
Curcuma / chemistry*
Malassezia / drug effects*
Microbial Sensitivity Tests
Phenols / pharmacology*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Phenols; 0/xanthorrhizol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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