Document Detail


In vitro anti-Helicobacter pylori activity of usnic acid.
MedLine Citation:
PMID:  19367654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eradication of Helicobacter pylori is an important objective in overcoming gastric diseases. Many regimens are currently available but none of them could achieve 100% success in eradication. Medicinal lichen is used in the treatment of gastric ulcer in local folk medicine in Anatolia (Turkey). The present study was performed to assess the in vitro effects of usnic acid from Usnea dasypoga against clinical isolates and standard H. pylori strains and their minimum inhibitory concentrations (MICs). A total of 38 strains was assayed for anti-H. pylori activity. The agar dilution method was used for the determination of usnic acid and clarithromycin resistance.Six (16.2%) clinical isolates were resistant to usnic acid and five (13.5%) were resistant to clarithromycin. Dual susceptibility to usnic acid and clarithromycin rate was detected as very high (97.3%). Usnic acid has a strong and dose-dependent activity against H. pylori strains. The synergism between usnic acid and clarithromycin may be effective in the treatment of H. pylori infection.
Authors:
Birol Safak; Ihsan Hakki Ciftci; Mehmet Ozdemir; Nilay Kiyildi; Zafer Cetinkaya; Orhan Cem Aktepe; Mustafa Altindis; Gulsah Asik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  23     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-25     Completed Date:  2009-07-27     Revised Date:  2009-07-30    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  955-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 John Wiley & Sons, Ltd.
Affiliation:
Department of Microbiology, Faculty of Medicine, Kocatepe University, Afyonkarahisar, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Benzofurans / pharmacology*
Clarithromycin / pharmacology
Dose-Response Relationship, Drug
Drug Resistance, Bacterial
Helicobacter pylori / drug effects*
Humans
Microbial Sensitivity Tests
Usnea / chemistry
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Benzofurans; 125-46-2/usnic acid; 81103-11-9/Clarithromycin
Comments/Corrections
Erratum In:
Phytother Res. 2009 Jul;23(7): i
Note: Asik, Gulsah [added]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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