Document Detail

In vitro activity of terpenes against Candida biofilms.
MedLine Citation:
PMID:  18440786     Owner:  NLM     Status:  MEDLINE    
The antibiofilm activity of 10 terpenes was tested in vitro against three Candida species by 24-h treatment of biofilms aged 1-5 days. Treatment of 24-h-old Candida albicans biofilms with carvacrol, geraniol or thymol (0.06%) resulted in >80% inhibition. Carvacrol (0.03%) inhibition was > or =75% independent of the age of the C. albicans biofilm. Carvacrol (0.125%) inhibition was >75% against Candida glabrata and Candida parapsilosis biofilms. Geraniol (> or =0.125%) and thymol (0.06% or 0.125%) inhibition was >75% against C. parapsilosis biofilms whatever their age. This study demonstrates the antibiofilm activity of terpenes and points out the exceptional efficiency of carvacrol, geraniol and thymol, which could represent candidates in the treatment of candidiasis associated with medical devices.
Stéphanie Dalleau; Estelle Cateau; Thierry Bergès; Jean-Marc Berjeaud; Christine Imbert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-28
Journal Detail:
Title:  International journal of antimicrobial agents     Volume:  31     ISSN:  0924-8579     ISO Abbreviation:  Int. J. Antimicrob. Agents     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111860     Medline TA:  Int J Antimicrob Agents     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  572-6     Citation Subset:  IM    
UMR 6008, Université de Poitiers, CNRS, 6 rue de la Milètrie, BP 199, 86034 Poitiers Cedex, France.
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MeSH Terms
Biofilms / drug effects*
Candida / drug effects*,  metabolism,  physiology*
Candidiasis / microbiology
Microbial Sensitivity Tests
Oils, Volatile / chemistry,  pharmacology
Terpenes / pharmacology*
Tetrazolium Salts
Reg. No./Substance:
0/Oils, Volatile; 0/Terpenes; 0/Tetrazolium Salts; 0/Thiazoles; 298-93-1/thiazolyl blue

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