Document Detail


In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria.
MedLine Citation:
PMID:  15273131     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report that intravenous injection (3 mg/kg of body weight twice daily) of a diastereomer (containing 33% D amino acids) of an antimicrobial peptide, K6L9 (LKLLKKLLKKLLKLL-NH2), but not the all-L-amino-acid parental peptide, cures neutropenic mice infected with gentamicin-sensitive Pseudomonas aeruginosa and gentamicin-resistant Acinetobacter baumannii bacteria. Various biophysical experiments suggest a membranolytic-like effect.
Authors:
Amir Braunstein; Niv Papo; Yechiel Shai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  48     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-26     Completed Date:  2004-09-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3127-9     Citation Subset:  IM    
Affiliation:
Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel.
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MeSH Terms
Descriptor/Qualifier:
Acinetobacter Infections / drug therapy,  microbiology
Acinetobacter baumannii / drug effects
Amino Acids / administration & dosage,  adverse effects,  therapeutic use*
Animals
Anti-Bacterial Agents / administration & dosage,  adverse effects,  therapeutic use*
Bacterial Infections / drug therapy*,  microbiology
Cell Membrane / drug effects
Drug Resistance, Bacterial
Female
Gentamicins / pharmacology
Injections, Intravenous
Mice
Microscopy, Confocal
Neutropenia / microbiology
Peptides / administration & dosage,  adverse effects,  therapeutic use*
Pseudomonas Infections / drug therapy,  microbiology
Pseudomonas aeruginosa / drug effects
Stereoisomerism
Trypsin / pharmacology
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Anti-Bacterial Agents; 0/Gentamicins; 0/Peptides; EC 3.4.21.4/Trypsin
Comments/Corrections

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