| In vitro activity of daptomycin against Staphylococci isolated from bacteremia and community-onset skin and soft tissue infections in France: data from two nationwide studies. | |
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MedLine Citation:
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PMID: 19499255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Staphylococci are a leading cause of skin and soft tissue infections (SSTIs) and bacteremia in France, a country with a high prevalence of oxacillin resistance. We evaluated the in vitro activity of daptomycin compared with reference compounds against 445 Staphylococcus aureus and 53 coagulase-negative Staphylococci (CNS) collected during two large nationwide studies performed in 2006 and 2007. The percentage of oxacillin resistance among S. aureus was 13.6% (SSTIs) and 30.7% (bacteremia). Daptomycin showed lower MIC(90) levels compared to vancomycin, teicoplanin, and linezolid (0.19 mg/L vs. 2, 1.5, and 1 mg/L, respectively), irrespective of oxacillin susceptibility. Amongst the CNS, 64.2% of the isolates originated from clinical bacteremia were resistant to oxacillin and 24.5% to teicoplanin; all but one Staphylococci were susceptible to daptomycin (MIC = 1.5 mg/l). As with linezolid, daptomycin seems to constitute an alternative option to treat some staphylococcal infections in the French context of high oxacillin resistance prevalence and high glycopeptides MIC. |
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Authors:
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O Gallon; C Guillet-Caruba; B Lamy; F Laurent; F Doucet-Populaire; J-W Decousser; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-06 |
Journal Detail:
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Title: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Volume: 28 ISSN: 1435-4373 ISO Abbreviation: Eur. J. Clin. Microbiol. Infect. Dis. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-02 Completed Date: 2009-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804297 Medline TA: Eur J Clin Microbiol Infect Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 1209-15 Citation Subset: IM |
Affiliation:
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Department of Biology and Infection Control, Centre Hospitalier de Dourdan, 91415, Dourdan, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology,
therapeutic use* Bacteremia / drug therapy*, microbiology Coagulase / metabolism Colony Count, Microbial Community-Acquired Infections / drug therapy, microbiology Daptomycin / pharmacology, therapeutic use* Dose-Response Relationship, Drug Drug Resistance, Bacterial France Humans Microbial Sensitivity Tests Oxacillin / pharmacology, therapeutic use Soft Tissue Infections / drug therapy*, microbiology Staphylococcal Infections / drug therapy*, microbiology Staphylococcal Skin Infections / drug therapy*, microbiology Staphylococcus / drug effects, enzymology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Coagulase; 103060-53-3/Daptomycin; 66-79-5/Oxacillin |
| Investigator | |
Investigator/Affiliation:
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Alba C Sauviat / ; C Auvray / ; C Bartizel / ; I Baudinat / ; E Benabid / ; Z Benseddik / ; F Bessis / ; H Biessy / ; M Bietrix / ; V Blanc / ; S Bland / ; M Y Boucaud / ; C Bouquigny / ; P Brisou / ; V Cailleaux / ; B Cancet / ; B Cartier-Riviere / ; B Cattier / ; A Cecille / ; G Chambreuil / ; C Chaplain / ; H Chardon / ; N Chioukh / ; E Collot / ; F Crepet / ; H De Montclos / ; J Delarbre / ; V Esteve / ; A Gravet / ; D Deligne / ; M C Demachy / ; V Doat / ; B Dubourdieu / ; S Dubourdieu / ; C Durand / ; El Harrif-Heraud / ; F Evreux / ; N Fonsale / ; S Gabriel / ; M Gavignet / ; F Geffroy / ; A Gravet / ; G Grise / ; P Guiet / ; I Hermes / ; J Heurte / ; E Heusse / ; J L Jacob / ; O Menouni / ; C Rigal / ; D Jan / ; E Jaouen / ; G Khatib / ; J P Lafargue / ; R Lamarcia / ; B Lamy / ; E Laurens / ; C Lebrun / ; Le Coustumier / ; E Lecaillon / ; C Lemble / ; S Leotard / ; M N Letouzey / ; A Mandjee / ; A Mangeol / ; A Marmonier / ; R Martin / ; M Menouar / ; Odile V Menouni / ; A Michel / ; D Neri / ; M J Noulard / ; X Palette / ; B Pangon / ; C Payen / ; D Pierrejean / ; J Pollet / ; H Porcheret / ; M Posson / ; A Raoult / ; F Richardin / ; C Rigal / ; O Sabot / ; S Samaille / ; R Sanchez / ; Y Scat / ; A Secher / ; D Simeon / ; J P Thellier / ; B Tourrans / ; A Vachee / ; Vasseur / ; I Verdier / ; A Verhaeghe / ; M Villemain / ; L Villeneuve / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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