Document Detail


In vitro activity of Ro 23-9424, a dual-action cephalosporin, compared with activities of other antibiotics.
MedLine Citation:
PMID:  2327765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro activity of Ro 23-9424, which is desacetyl-cefotaxime linked to fleroxacin, was compared with the activities of cefotaxime, desacetyl-cefotaxime, fleroxacin, ofloxacin, and ciprofloxacin. It inhibited the majority of members of the family Enterobacteriaceae, except for some Serratia marcescens, Citrobacter freundii, and Enterobacter cloacae strains, at less than or equal to 0.25 microgram/ml and had an MIC for 90% of strains tested (MIC90) of 8 micrograms/ml against Pseudomonas aeruginosa. Most group A, B, C, and G streptococci and Streptococcus pneumoniae were inhibited at less than or equal to 0.25 microgram/ml. Ninety percent of the staphylococci were inhibited at less than or equal to 4 micrograms/ml, except for some methicillin-resistant Staphylococcus aureus isolates. The MIC90S of Ro 23-9424 for Enterococcus faecalis and Listeria monocytogenes were greater than or equal to 16 micrograms/ml. Ninety percent of Clostridium perfringens isolates were inhibited by less than or equal to 2 micrograms/ml, whereas Bacteroides fragilis had an MIC90 of 32 micrograms/ml. There was a minimal inoculum size effect. The MICs and MBCs were either identical or within a twofold dilution. The MICs of Ro 23-9424 for Escherichia coli, Klebsiella pneumoniae, Serratia marcescens, Enterobacter cloacae, Citrobacter freundii, Pseudomonas aeruginosa, and Staphylococcus aureus increased 16- to 128-fold after 2 weeks of transfer in the presence of Ro 23-9424, showing that the presence of two agents does not prevent resistance.
Authors:
J W Gu; H C Neu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  34     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-05-16     Completed Date:  1990-05-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-95     Citation Subset:  IM    
Affiliation:
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Anti-Infective Agents / pharmacology*
Bacteria / drug effects*,  growth & development
Bacterial Infections / microbiology
Cefotaxime / analogs & derivatives*,  pharmacology
Ciprofloxacin / analogs & derivatives*,  pharmacology
Drug Resistance, Microbial
Fleroxacin* / analogs & derivatives*
Fluoroquinolones*
Humans
Microbial Sensitivity Tests
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Fluoroquinolones; 115622-58-7/Ro-23-9424; 63527-52-6/Cefotaxime; 79660-72-3/Fleroxacin; 85721-33-1/Ciprofloxacin
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