Document Detail


In vitro activity of JPC 2067 alone and in combination with sulfamethoxazole against nocardia species.
MedLine Citation:
PMID:  22106219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
JPC 2067 is a novel dihydrotriazine dihydrofolate reductase inhibitor that is being developed as an antimalarial therapeutic. We evaluated the in vitro activity of JPC 2067 alone and in combination with sulfamethoxazole (SMX) against a panel of nocardia isolates. The MIC(50)s and MIC(90)s for JPC 2067, SMX, and the combination were 0.125 μg/ml and 4 μg/ml, 16 μg/ml and 32 μg/ml, and 0.03 μg/ml and 2 μg/ml, respectively. JPC 2067 alone and in combination with SMX should be evaluated further to understand its clinical potential.
Authors:
Swagatam Mookherjee; Carolyn Shoen; Michael Cynamon
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Publication Detail:
Type:  Journal Article     Date:  2011-11-21
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  56     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-05-25     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1133-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, VAMC, Syracuse, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Drug Therapy, Combination
Humans
Microbial Sensitivity Tests / standards
Nocardia / classification,  drug effects*,  isolation & purification
Nocardia Infections / microbiology*
Sulfamethoxazole / pharmacology*
Tetrahydrofolate Dehydrogenase / drug effects
Triazines / chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Triazines; 723-46-6/Sulfamethoxazole; EC 1.5.1.3/Tetrahydrofolate Dehydrogenase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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