| In vitro activities of oral antimicrobial agents against penicillin-resistant Streptococcus pneumoniae: implications for outpatient treatment. | |
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MedLine Citation:
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PMID: 9191739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We tested 83 penicillin-intermediate (Peni) and 50 penicillin-resistant (Penr) isolates of Streptococcus pneumoniae against eight oral antimicrobials. Clarithromycin's MICs (minimal inhibitory concentration) were generally the same or one to two dilutions less than those of azithromycin. Seventy-two percent of Peni isolates were susceptible to clarithromycin and azithromycin, in contrast to 42% and 40%, respectively, of Penr isolates. Cefuroxime activity exceeded that of cefprozil, which exceeded that of cefaclor, in Peni isolates. For all three cephalosporins, MICs of 90% of isolates tested were > or = 3 dilutions higher for Penr isolates than for Peni isolates. Percentages of Peni isolates susceptible to clindamycin and tetracycline were 92% and 83%, respectively, and 78% and 82% for Penr. Only 49% of Peni isolates and 4% of Penr isolates were susceptible to trimethoprim-sulfamethoxazole. Azithromycin, clarithromycin, cefuroxime, cefprozil, clindamycin, and tetracycline may be useful in treating infections caused by Peni S pneumoniae, but Penr isolates are frequently resistant to both old and newer agents. |
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Authors:
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K Waites; E Swiatlo; B Gray; E Brookings |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Southern medical journal Volume: 90 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-07-10 Completed Date: 1997-07-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 621-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, University of Alabama at Birmingham 35233, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Ambulatory Care Anti-Bacterial Agents / administration & dosage, therapeutic use* Azithromycin / administration & dosage, therapeutic use Cefaclor / administration & dosage, therapeutic use Cefuroxime / administration & dosage, therapeutic use Cephalosporins / administration & dosage, therapeutic use Child Clarithromycin / administration & dosage, therapeutic use Clindamycin / administration & dosage, therapeutic use Culture Media Humans Penicillin Resistance* Pneumococcal Infections / drug therapy Streptococcus pneumoniae / drug effects* Tetracycline / administration & dosage, therapeutic use Trimethoprim-Sulfamethoxazole Combination / administration & dosage, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Cephalosporins; 0/Culture Media; 18323-44-9/Clindamycin; 53994-73-3/Cefaclor; 55268-75-2/Cefuroxime; 60-54-8/Tetracycline; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination; 81103-11-9/Clarithromycin; 83905-01-5/Azithromycin; 92665-29-7/cefprozil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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