Document Detail


In vitro action of PG F2 alpha on progesterone and cAMP synthesis in small bovine luteal cells.
MedLine Citation:
PMID:  3035616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The action of prostaglandin F2 alpha (PG F2 alpha) on incubated small bovine luteal cells in the presence or in the absence of bovine luteinizing hormone (LH) or dibutyryl cyclic adenosine monophosphate (db cAMP) was investigated. In the absence of LH and db cAMP, PG F2 alpha stimulated progesterone synthesis at concentrations of 10 ng/ml and 100 ng/ml but had no effects at concentrations below 1 ng/ml. PG F2 alpha partially inhibited the LH or db cAMP stimulated progesterone synthesis. This inhibition was maximal for PG F2 alpha concentrations around 100 pg/ml whereas distinctly higher or lower concentrations were without effect. At the concentration of 100 pg/ml, PG F2 alpha partially inhibited the LH induced cAMP accumulation. These results demonstrate an "in vitro" action of PG F2 alpha on bovine luteal cells. They indicate that the luteolytic action of PG F2 alpha in the bovine species could involve, as already suggested for the rat, both an inhibition of the LH induced synthesis of cAMP and an inhibition of the action of cAMP.
Authors:
A Benhaïm; P J Bonnamy; V Papadopoulos; H Mittre; P Leymarie
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins     Volume:  33     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-07-16     Completed Date:  1987-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-39     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bucladesine / antagonists & inhibitors,  pharmacology
Cattle
Corpus Luteum / drug effects*
Cyclic AMP / biosynthesis*
Dinoprost
Female
Luteal Cells / drug effects*,  metabolism
Luteinizing Hormone / antagonists & inhibitors,  pharmacology
Progesterone / biosynthesis*
Prostaglandins F / pharmacology*
Chemical
Reg. No./Substance:
0/Prostaglandins F; 362-74-3/Bucladesine; 551-11-1/Dinoprost; 57-83-0/Progesterone; 60-92-4/Cyclic AMP; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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