Document Detail

In vitro action of PG F2 alpha on progesterone and cAMP synthesis in small bovine luteal cells.
MedLine Citation:
PMID:  3035616     Owner:  NLM     Status:  MEDLINE    
The action of prostaglandin F2 alpha (PG F2 alpha) on incubated small bovine luteal cells in the presence or in the absence of bovine luteinizing hormone (LH) or dibutyryl cyclic adenosine monophosphate (db cAMP) was investigated. In the absence of LH and db cAMP, PG F2 alpha stimulated progesterone synthesis at concentrations of 10 ng/ml and 100 ng/ml but had no effects at concentrations below 1 ng/ml. PG F2 alpha partially inhibited the LH or db cAMP stimulated progesterone synthesis. This inhibition was maximal for PG F2 alpha concentrations around 100 pg/ml whereas distinctly higher or lower concentrations were without effect. At the concentration of 100 pg/ml, PG F2 alpha partially inhibited the LH induced cAMP accumulation. These results demonstrate an "in vitro" action of PG F2 alpha on bovine luteal cells. They indicate that the luteolytic action of PG F2 alpha in the bovine species could involve, as already suggested for the rat, both an inhibition of the LH induced synthesis of cAMP and an inhibition of the action of cAMP.
A Benhaïm; P J Bonnamy; V Papadopoulos; H Mittre; P Leymarie
Related Documents :
25246746 - Anti-müllerian hormone levels in the follicular fluid of the preovulatory follicle: a p...
11518916 - Umbilical arteritis and phlebitis mark different stages of the fetal inflammatory respo...
8686976 - The association between mortality rates and decreased concentrations of interleukin-10 ...
15249726 - Th1 and th2 serum cytokine profiles characterize patients with hashimoto's thyroiditis ...
8546756 - Evaluation of oxidative stress in patients with hyperlipidemia.
24683946 - Diagnosis and evaluation of hypogonadism.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins     Volume:  33     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-07-16     Completed Date:  1987-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-39     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bucladesine / antagonists & inhibitors,  pharmacology
Corpus Luteum / drug effects*
Cyclic AMP / biosynthesis*
Luteal Cells / drug effects*,  metabolism
Luteinizing Hormone / antagonists & inhibitors,  pharmacology
Progesterone / biosynthesis*
Prostaglandins F / pharmacology*
Reg. No./Substance:
0/Prostaglandins F; 362-74-3/Bucladesine; 551-11-1/Dinoprost; 57-83-0/Progesterone; 60-92-4/Cyclic AMP; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether.
Next Document:  Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonucle...