Document Detail


In vitro fermentation of sugar beet arabino-oligosaccharides by fecal microbiota obtained from patients with ulcerative colitis to selectively stimulate the growth of Bifidobacterium spp. and Lactobacillus spp.
MedLine Citation:
PMID:  21984234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential prebiotic properties of arabino-oligosaccharides (AOS) derived from sugar beet pulp was studied using mixed cultures of human fecal bacteria from patients with ulcerative colitis (UC), in remission or with active disease, and in healthy controls. These results were compared to those for fructo-oligosaccharides (FOS), which are known to have a prebiotic effect. Fermentation studies were carried out using a small-scale static batch system, and changes in the fecal microbial communities and metabolites were monitored after 24 h by quantitative real-time PCR and short-chain fatty acid analysis. With a few minor exceptions, AOS affected the communities similarly to what was seen for FOS. Quantitative real-time PCR revealed that Bifidobacterium spp. and Lactobacillus spp. were selectively increased after fermentation of AOS or FOS by fecal microbiota derived from UC patients. The stimulation of growth of Lactobacillus spp. and Bifidobacterium spp. was accompanied by a high production of acetate and hence a decrease of pH. The fermentation of AOS may help improve the inflammatory conditions in UC patients through stimulation of bacteria eliciting anti-inflammatory responses and through production of acetate. AOS may therefore represent a new prebiotic candidate for reduction of the risk of flare-ups in UC patients. However, human trials are needed to confirm a health-promoting effect.
Authors:
Louise Kristine Vigsnæs; Jesper Holck; Anne S Meyer; Tine Rask Licht
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-07
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  77     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-17     Completed Date:  2012-03-07     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8336-44     Citation Subset:  IM    
Affiliation:
National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 Søborg, Denmark. lokv@food.dtu.dk
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MeSH Terms
Descriptor/Qualifier:
Acetates / metabolism
Beta vulgaris / chemistry*
Bifidobacterium / growth & development*,  isolation & purification,  metabolism
Biodiversity*
Colitis, Ulcerative / microbiology*
Feces / microbiology*
Fermentation
Humans
Hydrogen-Ion Concentration
Lactobacillus / growth & development*,  isolation & purification,  metabolism
Oligosaccharides / metabolism*
Prebiotics
Real-Time Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Acetates; 0/Oligosaccharides; 0/Prebiotics
Comments/Corrections

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