| In vitro Doppler ultrasound investigation of turbulence intensity in pulsatile flow with simulated cardiac variability. | |
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MedLine Citation:
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PMID: 18950931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An in vitro investigation of turbulence intensity (TI) associated with a severe carotid stenosis in the presence of physiological cardiac variability is described. The objective of this investigation was to determine if fluctuations due to turbulence could be quantified with conventional Doppler ultrasound (DUS) in the presence of normal physiological cycle-to-cycle cardiac variability. An anthropomorphic model of a 70% stenosed carotid bifurcation was used in combination with a programmable flow pump to generate pulsatile flow with a mean flow rate of 6 mL/s. Utilizing the pump, we studied normal, nonrepetitive cycle-to-cycle cardiac variability (+/-3.9%) in flow, as well as waveform shapes with standard deviations equal to 0, 2 and 3 times the normal variation. Eighty cardiac cycles of Doppler data were acquired at two regions within the model, representing either laminar or turbulent flow; each measurement was repeated six times. Turbulence intensity values were found to be 11 times higher (p < 0.001), on average, in the turbulent region than in the laminar region, with a mean difference of 24 cm/s. Twenty cardiac cycles were required for confidence in TI values. In conclusion, these results indicate that it is possible to quantify TI in vitro, even in the presence of normal and exaggerated cycle-to-cycle cardiac variability. |
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Authors:
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Meghan L Thorne; Tamie L Poepping; Hristo N Nikolov; Richard N Rankin; David A Steinman; David W Holdsworth |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-31 |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 35 ISSN: 1879-291X ISO Abbreviation: Ultrasound Med Biol Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 120-8 Citation Subset: IM |
Affiliation:
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Robarts Research Institute, London, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Carotid Arteries / ultrasonography* Carotid Stenosis / ultrasonography* Humans Phantoms, Imaging Pulsatile Flow Signal Processing, Computer-Assisted* Ultrasonography, Doppler, Pulsed / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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