Document Detail

In vitro antifungal susceptibility pattern and ergosterol content in clinical yeast strains.
MedLine Citation:
PMID:  21251996     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Absence or severe reduction in the amount of ergosterol in the fungal membrane and its replacement with other sterols have been described as potential antifungal resistance mechanisms in fungi.
AIMS AND METHODS: The ergosterol content in a collection of 51 clinical yeast isolates, including susceptible and resistant strains to amphotericin B and azoles, was estimated by a simple chromatographic method (HPLC-UV).
RESULTS: A high content of ergosterol was detected for several strains of Candida glabrata, Candida tropicalis or Pichia membranifaciens. In contrast, strains of Cryptococcus neoformans and Dipodascus capitatus had the lowest ergosterol concentrations. No significant correlation was observed between antifungal susceptibility patterns and ergosterol content.
CONCLUSIONS: We conclude from this study that ergosterol content on yeasts may not be associated with specific resistant patterns.
Alicia Gomez-Lopez; María Jose Buitrago; Juan Luis Rodriguez-Tudela; Manuel Cuenca-Estrella
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Publication Detail:
Type:  Journal Article     Date:  2011-01-18
Journal Detail:
Title:  Revista iberoamericana de micología     Volume:  28     ISSN:  2173-9188     ISO Abbreviation:  Rev Iberoam Micol     Publication Date:    2011 Apr-Jun
Date Detail:
Created Date:  2011-05-09     Completed Date:  2011-11-15     Revised Date:  2012-08-31    
Medline Journal Info:
Nlm Unique ID:  9425531     Medline TA:  Rev Iberoam Micol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  100-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier Espana.
Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, España.
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MeSH Terms
Antifungal Agents / pharmacology*
Drug Resistance, Fungal
Ergosterol / biosynthesis*
Microbial Sensitivity Tests
Yeasts / drug effects*,  metabolism*
Reg. No./Substance:
0/Antifungal Agents; 57-87-4/Ergosterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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