Document Detail


In vitro 31P NMR spectroscopy detects altered phospholipid metabolism in Alzheimer's disease.
MedLine Citation:
PMID:  3791069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to study possible metabolic derangements in Alzheimer's disease (AD), we performed phosphorus 31 nuclear magnetic resonance (31P NMR) spectroscopy on brain samples obtained at autopsy from 7 patients with AD and 9 control subjects. Aqueous solutions of brain tissue contained well-defined peaks of intermediate compounds in phospholipid metabolism, including the phosphomonoesters phosphocholine and phosphoethanolamine, and the phosphodiesters glycerophosphorylcholine and glycerophosphorylethanolamine. 31P NMR spectra also displayed the inorganic phosphorus signal, which provides an index to the in vivo concentration of high-energy compounds. We found evidence for altered phospholipid metabolism in that relative levels of phosphomonoesters were decreased, and phosphodiesters increased, in frontal and parietal regions of patients with AD compared to control subjects. The inorganic phosphorus resonance peaks were similar in AD and control subjects, suggesting that energy stores are not diminished in AD. These preliminary data are consistent with the hypothesis that abnormalities in phospholipid metabolism contribute to possible neuronal membrane dysfunction and impaired cholinergic neurotransmission in AD.
Authors:
O Miatto; R G Gonzalez; F Buonanno; J H Growdon
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  13     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-02-06     Completed Date:  1987-02-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  535-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / metabolism*
Brain / metabolism
Humans
Magnetic Resonance Spectroscopy
Phospholipids / metabolism*
Phosphorus / diagnostic use
Spectrum Analysis
Grant Support
ID/Acronym/Agency:
AG 04512-1/AG/NIA NIH HHS; MH 31154/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Phospholipids; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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